Solitary nasal neurofibroma presenting as compressive optic neuropathy

Chua, C N; Alhady, Mohammed El-Gebaly Ahmed; Ngo, C T; Swethadri, Gumballi Krishnamurthy; Singh, Avatar Singh Mohan; Tan, S.S.N.

doi:10.1038/sj.eye.6702261

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…Common clinical manifestations include local swelling, pain, nasal congestion or runny nose as well as epistaxis or facial discomfort; occasionally invading the orbit can lead to exophthalmos and visual impairment, 4 invading alveolar bone can lead to tooth loosening or abnormal occlusion, 2 and invading brain tissue can cause headaches. 17 Solitary NFs differ from NF1 related ones due to lack of common skin coffee spots or family history associated with them. 5 …”

Section: Discussionmentioning

confidence: 99%

Unusual paranasal sinus solitary neurofibroma and literature review

Yang,

Chen

2023

BJR|case reports

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Neurofibroma (NF) is a common benign peripheral neurogenic tumor that is rarely encountered in the paranasal sinus tract. In this report, we present a 55-year-old female who serendipitously discovered a maxillary sinus NF during a medical examination for a pulmonary nodule. The purpose of this article is to enhance medical practitioners' comprehension of paranasal sinus solitary NF by exploring cases, summarizing occurrences located in the paranasal sinus tract and conducting an organized review of paranasal sinus tract NF.

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Section: Discussionmentioning

confidence: 99%

Unusual paranasal sinus solitary neurofibroma and literature review

Yang,

Chen

2023

BJR|case reports

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“…Although rare, PNSTs arising in the nasal cavity are a well-known entity in man. Neurofibroma, in particular, may occur singly or as a part of the syndrome of neurofibromatosis (both type I and type II neurofibromatosis) (Chua et al 2006). This case report showed the histological features of a PNST, with prominent features of the diffuse neurofibroma.…”

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Peripheral nerve sheath tumor invading the nasal cavities of a 6-year-old female Pointer dog

Sfacteria

Perillo

Macrı̀

et al. 2015

Veterinary Quarterly

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Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

Azani

Bishop

Thompson

2014

Head and Neck Pathol

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Neurofibroma (NF), a benign peripheral nerve sheath tumor, is very uncommon in the sinonasal tract, with only a few reported cases in the English literature. Cases within the files of the authors' institutions confined to the sinonasal tract were compared to cases reported in the English literature (Medline 1966-2014). The 12 patients included 6 females and 6 males, aged 26-75 years (mean 46.2 years). The patients usually presented clinically with a mass lesion (n = 11), obstruction (n = 4) or pain (n = 3), with an average symptom duration of 42.9 months. Two patients had neurofibromatosis (NF1). Tumors involved the nasal cavity alone (n = 8), maxillary sinus alone (n = 2), or mixed sites (n = 2), with a range of 0.4-4.1 cm (mean 2.2 cm). The tumors were circumscribed, composed of spindled to wavy cells with curvilinear nuclei set in a background of collagenized stroma and mast cells. Nuclear palisading and perivascular hyalinization were not seen. Mitoses were scant. Pleomorphism, necrosis and increased cellularity were absent. By immunohistochemistry, the lesional cells were S100 protein, SOX10 and NFP positive, while CD34 highlighted the perineurium. INI1 was intact, with strong nuclear expression in all cases. All patients had surgical excision without recurrence (mean follow-up 8.6 years). The principle differential diagnoses include schwannoma, perineurioma, fibromatosis, and solitary fibrous tumor. NF of the sinonasal tract occurs in middle-aged patients without a gender predilection, usually with non-specific symptoms present for a long duration. Tumors are relatively large (mean 2.2), and usually affect one site only. Surgery is curative, with only 16.7 % NF1 associated. S100 protein, SOX10 and NFP highlight the Schwann cells, with CD34 highlighting the perineural fibroblasts.

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Solitary nasal neurofibroma presenting as compressive optic neuropathy

Cited by 7 publications

References 5 publications

Unusual paranasal sinus solitary neurofibroma and literature review

Unusual paranasal sinus solitary neurofibroma and literature review

Peripheral nerve sheath tumor invading the nasal cavities of a 6-year-old female Pointer dog

Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

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