Solitary Neuroblastoma in the Scapula

Abstract

Majority of primary pediatric neuroblastomas occur in the abdomen, followed by posterior mediastinum. A 7-year-old girl presented worsening pain in the left shoulder, and a CT image of the chest revealed osseous destruction in the left scapula, suggestive of bone tumor. A biopsy was performed. Pathological result was consistent with neuroblastoma. A 123I scan with SPECT/CT images was performed, which showed only increased activity in the left scapula without any other foci of abnormal activity elsewhere.

18F-MFBG PET/CT and MRI in Identifying Brain Metastases in a Posttreatment Neuroblastoma Patient

“…New findings in the left cerebellopontine angle and internal auditory canal showed equal T1 ( D ) and T2 ( E ) signals with abnormal enhancement ( F ), corresponding to the sites of increased MFBG activity on prior PET/CT study. Currently, 123 I-MIBG SPECT/CT is the most common nuclear medicine imaging modality in the evaluation of patients with neuroblastoma with reasonable accuracy, 1–4 whereas 18 F-MFBG PET/CT had only recently been proposed as a potential alternative in the evaluation of different neural crest tumors 5–7 . In patients with metastatic pheochromocytomas and paragangliomas, MFBG PET/CT offers a similar or slightly better accuracy than DOTATATE PET/CT 8 .…”