Solitary Neurofibroma of the Breast, and “The Man From Istanbul” Syndrome

Cheng, Esther; Viswanathan, Kartik; Hoda, Syed A.

doi:10.1177/1066896917728337

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…Neurofibromas arising within the breast parenchyma are extremely rare, and only three cases have been reported in which the neurofibroma was clearly identifiable on imaging as a neurofibroma within the mammary tissue [ 6 – 8 ]. Of these three case reports, two had tumors locating closer to the chest wall than within the breast [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

Neurofibroma with adenosis in the mammary gland: a case report

et al. 2023

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Background Neurofibroma of the breast is extremely rare, with only a few reported cases. Here, we report a case of solitary neurofibroma of the breast in a 95-year-old woman. Case presentation A 95-year-old woman presented with a palpable mass in the left breast. Mammography revealed a well-defined mass. A 1.6-cm round mass was found in the lower outer quadrant of the left breast on ultrasonography. The internal echo of the tumor was a mixture of relatively uniform hypoechoic areas with posterior enhancement and heterogeneous hyperechoic areas. She underwent a core needle biopsy. The pathological findings revealed a spindle cell lesion with no malignant findings. At 2 months follow-up, repeat breast ultrasonography showed that the mass had enlarged to be 2.7 cm in size. A repeat core needle biopsy, however, revealed no particularly new information. Because the tumor was growing and a definite diagnosis was not made, lumpectomy was performed. We found bland-spindled cells with shredded-carrot collagen bundles. Immunohistochemical antibody markers (S100, SOX10, and CD34) were positive for the spindle cells. Some of the tumors maintained the bilayer nature of luminal cells and myoepithelial cells, which might be the reason for internal heterogeneity on ultrasound. A histological diagnosis of neurofibroma with adenosis was made. At 6 months follow-up, no recurrent lesions were found. Conclusions Ultrasound and pathological images revealed an extremely rare case of neurofibroma combined with adenosis. Tumor resection was performed because it was difficult to make a definitive diagnosis using needle biopsy. Even when a benign tumor is suspected, short-term follow-up is necessary, and if an enlargement is observed, early tumor resection is recommended.

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Section: Discussionmentioning

confidence: 99%

Neurofibroma with adenosis in the mammary gland: a case report

et al. 2023

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confidence: 84%

“…The breast is a rare localization for solitary neurofibromas, with only a few cases reported in the literature. 1,4 To the best of our knowledge, ours is the first case of a solitary neurofibroma of the areola, especially considering its peculiar shape, location, and pigmentation that makes it very similar to the neighboring true nipple. 5 Lesions of the breast skin have a wide differential diagnosis because they are not restricted to cutaneous conditions, but they include conditions affecting the soft tissue, 6 the lymphoid system, 7 and the mammary tissue proper.…”

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confidence: 85%

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Nervous Nipple: Pseudopolythelia Caused by a Neurofibroma of the Areola

Caputo

Addesso

D’Antonio

2021

The American Journal of Dermatopathology

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The presence of a supernumerary nipple inside the original areola is a rare condition termed intra-areolar polythelia. Rarely, a lesion can macroscopically resemble a nipple. We report a case of a solitary neurofibroma (by itself rare in the areola) mimicking a second, twin nipple. In this case, these 2 rare conditions merge resulting in pseudopolythelia. The relevant literature on polythelia and neurofibromas of the breast is briefly reviewed.

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Solitary Neurofibroma of the Breast, and “The Man From Istanbul” Syndrome

Cited by 2 publications

References 5 publications

Neurofibroma with adenosis in the mammary gland: a case report

Neurofibroma with adenosis in the mammary gland: a case report

Nervous Nipple: Pseudopolythelia Caused by a Neurofibroma of the Areola

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