Solitary Neurofibroma of the Floor of the Mouth: A Case Report

Maruyama, Motoyoshi; Fushiki, Hiroaki; Watanabe, Yukio

doi:10.1155/2011/967896

Cited by 16 publications

(24 citation statements)

References 6 publications

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“…[ 4 ] The following are the common distribution found in the literature: Tongue, palate, mandibular ridge/vestibule, maxillary ridge/vestibule, buccal mucosa, lip, gingiva. [ 2 ] The tongue is the most common site affected. [ 5 ] The base of the tongue is a relatively rare location and it is important to note in this context that tumors in this region may lead to an upper airway obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…When a neurofibroma grows in the head and neck region, it presents with symptoms, such as upper airway obstruction, swallowing difficulty, mastication deficits, or cosmetic distortion of the face. [ 2 ] Microscopically the tumor is composed of an irregular pattern of proliferative spindle cells. The stroma is composed of collagen fibers and mucoid masses.…”

Section: Introductionmentioning

confidence: 99%

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Solitary neurofibroma at the base of the tongue: A rare presentation

Roy¹,

Chakraborty²,

Das

et al. 2015

Indian J Dermatol

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A 75-year-old man presented with a slowly growing mass at the right side of the base of the tongue for 4 months. The mass was painless initially but had become very painful during preceding 4 weeks. On examination a 3 cm diameter, oval swelling was observed at the right side of the base of the tongue. It was firm in consistency, slightly tender, non-ulcerative, and with irregular surface. A deep incisional biopsy was taken from mass under general anesthesia. Histopathology report identified the mass consistent with neurofibroma. It featured typical pallisading arrangement of fascicles of spindle-shaped cells and there was no evidence of malignancy. An absence of Verocay body and thick hyalinized vessels ruled out Schwannoma. No similar lesions were found in any other part of the patient's body. He exhibited no skin pigmentation, no hearing deficit, and no evidence suggestive of any systemic disorders that might have been attributable to the tongue base neurofibroma. His family history was also negative. Thus, a diagnosis of isolated neurofibroma of the tongue was established. The patient was advised excision of the mass but he refused and lost in follow up.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solitary neurofibroma at the base of the tongue: A rare presentation

Roy¹,

Chakraborty²,

Das

et al. 2015

Indian J Dermatol

View full text Add to dashboard Cite

show abstract

“…[568] It is unencapsulated and composed of mixture of Schwann, perineural-like and fibroblastic cell. [8] Also, NF is immunopositive for S-100 protein, indicating its neural origin.…”

Section: Discussionmentioning

confidence: 99%

Unusual solitary neurofibroma on the lower lip of a child

et al. 2013

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Neurofibromas (NF) are benign tumors with involvement of the peripheral nerve, which is not frequently located in the oral cavity, and especially, extraordinary rarity on lower lip of a child. This report describes a case of a NF on lower lip in a 12-year-old Brazilian child. NF consists of a wide variety of cell types, including Schwann cells, perineurial cells, and fibroblasts. Due to cellular heterogeneity, several hypotheses have been proposed to explain the histogenesis of this lesion. One of them, it support an origin of Schwannian, while others emphasize the participation of both Schwann cells and perineural cells. Excisional biopsy was performed to establish definitive diagnosis. Microscopically, the lesion was composed of interlacing bundles of elongated cells with wavy nuclei and small nerve fibers. Immunohistopathologic assessment showed cells positive for S-100, confirming the diagnosis of NF. No recurrence was observed after 1-year follow-up. Pediatric dentists must have a thorough knowledge of this unusual lesion.

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“…There, they lead to macroglossia and enlargement of the fungiform papillae [26] [35] [36]. These benign tumors may also be located on the palate [37], lips [38] and floor of the mouth [38]. Plexiform neurofibromas, which can be considered a diagnostic criterion for NF-1, are rarely located in the oral cavity [30].…”

Section: Oral Mucosal Pathologymentioning

confidence: 99%

Oral Manifestations of Neurofibromatosis Type 1

Chérifi¹,

Fournier²,

Berdal³

et al. 2019

JCDSA

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Neurofibromatosis type 1 (NF-1) is a common genetic disorder with a highly variable phenotype. The disease affects both proliferation and differentiation of cells of neurectodermal origin. The presence of tumors is very common like benign nodular neurofibromas. Tumors with unclear prognosis may be present like plexiform neurofibromas whose prognosis is more uncertain. While many organs exhibit pathologies, most commonly affected are the nervous system, skin, gastrointestinal tract and heart. Oral abnormalities are also very common: 72% of NF-1 patients exhibit pathologies in oral mucosa, gums, maxillary and temporomandibular joints, and teeth. The incidence of NF-1 and its relationship to the prevalence of caries have been discussed in other researches. It is known that poor oral hygiene plays a key role in the development of periodontal disease and caries. Here we review the oral manifestations of neurofibromatosis type 1 that we illustrate by a patient followed in the center of rare diseases of the hospital Henri Mondor, clinical service in which we work.

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Solitary Neurofibroma of the Floor of the Mouth: A Case Report

Cited by 16 publications

References 6 publications

Solitary neurofibroma at the base of the tongue: A rare presentation

Solitary neurofibroma at the base of the tongue: A rare presentation

Unusual solitary neurofibroma on the lower lip of a child

Oral Manifestations of Neurofibromatosis Type 1

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