Solitary Neurofibroma of the Frontal Sinus

Sharma, Sudhir B.; Hong, Paul

doi:10.1155/2012/373808

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…The exact cause of IGN is not well understood, but it is believed to be either sporadic or associated with neurofibromatosis (NF) [ 1 ]. NF is a genetic disorder characterized by the growth of tumors on the nerves, and it may present with IGN or schwannomas [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Sporadic neurofibroma of facial nerve presenting as parotid gland tumor: a rare case report

Hassan,

Salih,

Salih

et al. 2024

Journal of Surgical Case Reports

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Intraparotid gland neurofibroma is a rare benign tumor that arises from Schwann cells of the facial nerve within the parotid gland. This case report discusses a 41-year-old woman who experienced a painless preauricular swelling on her right side for over 5 years. Clinical examination and ultrasound revealed a well-defined mass in the parotid gland. The patient underwent total mass excision, resulting in transient facial nerve dysfunction but complete recovery. These tumors often manifest as solitary masses in the parotid region and may compress nearby structures, causing facial paralysis or numbness. Their diagnosis can be challenging due to similarities with other parotid gland tumors and possible associations with neurofibromatosis. Managing intraparotid tumors, including neurofibromas, involves a multidisciplinary approach with input from cytopathologists, radiologists, and surgeons.

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Section: Introductionmentioning

confidence: 99%

Sporadic neurofibroma of facial nerve presenting as parotid gland tumor: a rare case report

Hassan,

Salih,

Salih

et al. 2024

Journal of Surgical Case Reports

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show abstract

“…[ 2 ] Histologically, NF is composed by ovoids or fusiforms cells, with scanty cytoplasm, inserted in a matrix with variable amount of mucine and collagenous, organized in little fascicles, coiled or in diffused distributed pattern. [ 3 4 ] The cells of NFs show divergent differentiation between them. The use of immunohistochemistry is necessary to determine the presence of Schwann cell, perineurial cell, and fibroblast differentiation.…”

Section: Introductionmentioning

confidence: 99%

“…In the head and neck region, the NF can be cutaneous, mucosal or related to deep nervous bundle, which can be to the facial, glossopharyngeus, vague or hippoglossus nerves. [ 2 4 6 ] Solitary NF is not common in the oral cavity and a few cases in the literature are written. [ 1 6 7 8 ] In approximately 6% of the cases, they may occur in the oral cavity and rarely affect lower lips.…”

Section: Introductionmentioning

confidence: 99%

Unusual solitary neurofibroma on the lower lip of a child

et al. 2013

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Neurofibromas (NF) are benign tumors with involvement of the peripheral nerve, which is not frequently located in the oral cavity, and especially, extraordinary rarity on lower lip of a child. This report describes a case of a NF on lower lip in a 12-year-old Brazilian child. NF consists of a wide variety of cell types, including Schwann cells, perineurial cells, and fibroblasts. Due to cellular heterogeneity, several hypotheses have been proposed to explain the histogenesis of this lesion. One of them, it support an origin of Schwannian, while others emphasize the participation of both Schwann cells and perineural cells. Excisional biopsy was performed to establish definitive diagnosis. Microscopically, the lesion was composed of interlacing bundles of elongated cells with wavy nuclei and small nerve fibers. Immunohistopathologic assessment showed cells positive for S-100, confirming the diagnosis of NF. No recurrence was observed after 1-year follow-up. Pediatric dentists must have a thorough knowledge of this unusual lesion.

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Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

Azani

Bishop

Thompson

2014

Head and Neck Pathol

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Neurofibroma (NF), a benign peripheral nerve sheath tumor, is very uncommon in the sinonasal tract, with only a few reported cases in the English literature. Cases within the files of the authors' institutions confined to the sinonasal tract were compared to cases reported in the English literature (Medline 1966-2014). The 12 patients included 6 females and 6 males, aged 26-75 years (mean 46.2 years). The patients usually presented clinically with a mass lesion (n = 11), obstruction (n = 4) or pain (n = 3), with an average symptom duration of 42.9 months. Two patients had neurofibromatosis (NF1). Tumors involved the nasal cavity alone (n = 8), maxillary sinus alone (n = 2), or mixed sites (n = 2), with a range of 0.4-4.1 cm (mean 2.2 cm). The tumors were circumscribed, composed of spindled to wavy cells with curvilinear nuclei set in a background of collagenized stroma and mast cells. Nuclear palisading and perivascular hyalinization were not seen. Mitoses were scant. Pleomorphism, necrosis and increased cellularity were absent. By immunohistochemistry, the lesional cells were S100 protein, SOX10 and NFP positive, while CD34 highlighted the perineurium. INI1 was intact, with strong nuclear expression in all cases. All patients had surgical excision without recurrence (mean follow-up 8.6 years). The principle differential diagnoses include schwannoma, perineurioma, fibromatosis, and solitary fibrous tumor. NF of the sinonasal tract occurs in middle-aged patients without a gender predilection, usually with non-specific symptoms present for a long duration. Tumors are relatively large (mean 2.2), and usually affect one site only. Surgery is curative, with only 16.7 % NF1 associated. S100 protein, SOX10 and NFP highlight the Schwann cells, with CD34 highlighting the perineural fibroblasts.

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Solitary Neurofibroma of the Frontal Sinus

Cited by 6 publications

References 11 publications

Sporadic neurofibroma of facial nerve presenting as parotid gland tumor: a rare case report

Sporadic neurofibroma of facial nerve presenting as parotid gland tumor: a rare case report

Unusual solitary neurofibroma on the lower lip of a child

Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

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