Solitary plasmacytoma of the mandible: report of two cases

Küçükkurt, Sercan; Karan, Nazife Begüm; Şengüven, Burcu; Kahraman, Sibel

doi:10.1136/bcr-2015-214255

Cited by 6 publications

(10 citation statements)

References 9 publications

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“…SP in maxillofacial bones needs to be differentiated from a variety of single destructive osteolytic tumors, such as ameloblastoma, odontogenic keratocyst, primary intraosseous squamous cell carcinoma of the jaw and osteosarcoma. 3 Ameloblastoma occurs mostly in young adults aged 20-40 years, with no gender difference. Ameloblastoma usually occurs in the mandibular molar region and the ramus of the mandible.…”

Section: Discussionmentioning

confidence: 99%

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Solitary plasmacytoma of maxillofacial bones: correlation of CT features with pathological findings

Liu

2020

Dentomaxillofacial Radiology

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Objective: To explore the CT features of solitary plasmacytoma (SP) of maxillofacial bones and correlation with pathological findings. Methods and materials: We retrospectively reviewed the clinical, CT and pathological features of SP in the maxillofacial bones. 16 patients with clinically and histologically proven SP of maxillofacial bones were involved. They were aged from 27 to 79 years old (median 55.5 years old), and included 12 males and 4 females (males vs females: 3:1). All patients performed CT examination, in whom 13 patients underwent enhanced scanning and 3 plain scanning. The CT images were assessed for lesion location, size (maximum diameter), shape (round, oval and irregular), boundary (defined and illdefined), bone changes (bone destruction, residual bone, sclerotic margin and periosteal reaction), density of soft tissue mass and enhancement manifestations, and invasion of adjacent structures. Results: 13 patients suffered from SP in the mandible, 2 in the zygoma, and 1 in the maxilla and hard palate. The maximum diameter of lesions ranged from 2.4 to 8.2 cm (mean 3.93 ± 1.435 cm). Most lesions were founded as a solitary osteolytic lesions (15/16, 93.75%) with round or ovoid shape (13/16, 81.25%), smooth margin (16/16, 100%) and defined boundary (16/16, 100%) in bone marrow. They destroyed bone cortex (15/16, 93.75%) and had residual bone (10/16, 62.5%), without sclerosis margin (15/16, 93.75%) and periosteal reaction (14/16, 87.5%). They easily formed soft tissue masses (16/16, 100%) and invade adjacent anatomical structures (15/16, 93.75%). The density of lesions was usually uniform (12/16, 75%) with strong enhancement. There was a significant difference in CT values between plain and enhanced scanning [50.75 ± 9.140 Hounfield unit (HU) vs 101.0 ± 28.830 HU; p < 0.001), with the mean difference of CT values 50.25 HU. Conclusions: SP is predominant in the mandible of elderly male patients. A solitary, round or ovoid, well-defined, osteolytic, invasive mass in bone marrow, which destroys bone cortex, has residual bone, no sclerosis margin and periosteal reaction, and shows strong enhancement, is suggestive of this diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…It is reported that the incidence of SP in mandible is 4.4% within the maxillofacial regions. 3 The incidence of SP in maxillofacial bone is low and its clinical symptoms are not specific. So the clinical diagnosis of SP in maxillofacial bones is quite difficult and often leads to misdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

Solitary plasmacytoma of maxillofacial bones: correlation of CT features with pathological findings

Liu

2020

Dentomaxillofacial Radiology

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“…9 Studies have reported that in most cases, lesions were observed in the maxilla rather than the mandible. 10 However, there are also reports of anterior mandibular lesions. In this particular case, the lesion was observed in a woman and located in the anterior region of the mandible.…”

Section: Fig 7: Imwg Criteria For Diagnosis Of Myelomamentioning

confidence: 99%

Solitary plasmacytoma masquerading as a benign lesion

Akbar,

Abhilash,

Radhakrishna

2023

JOOO

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Plasmacytoma refers to a distinct and localized growth of plasma cells that are neoplastic and monoclonal in nature. Solitary plasmacytomas (SP) can be categorized into two groups based on their location: solitary bone plasmacytoma (SBP), which most commonly occurs in the vertebrae and secondarily in long bones, and extramedullary plasmacytoma (EMP), encompassing SPs found outside the bone. Long bones are frequently affected in solitary plasmacytomas. SBP specifically in the jaw is a rare condition, leading to challenges in diagnosis and often resulting in misdiagnosis. SBP carries a higher risk of progression to myeloma, and the primary treatment option is radiotherapy (RT). By employing RT alone, approximately 30% of SBP patients and 65% of EMP patients can achieve long-term disease-free survival (DFS). This article presents a case of a 40-year-old female patient diagnosed with solitary plasmacytoma of the mandible, with detailed documentation of clinical, radiographic, and histological features.

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“…SOPs are a rare subset of plasmacytic tumours found in the vertebrae, long bones, zygomatic arch or ribs of dogs (MacEwen et al 1984, Matus et al 1986, Rusbridge et al 1999, Vail et al 2020. In humans, these plasma cell tumours of bone are more commonly referred to as solitary bone plasmacytomas (SBPs) and occur most commonly in the vertebrae, femur and pelvis, though mandibular and maxillary forms have been described (Anil 2007, Kucukkurt et al 2016. It is a rare disease in humans, and men are diagnosed twice as frequently as women (Pham & Mahindra 2019).…”

Section: Introductionmentioning

confidence: 99%

“…In humans, these plasma cell tumours of bone are more commonly referred to as solitary bone plasmacytomas (SBPs) and occur most commonly in the vertebrae, femur and pelvis, though mandibular and maxillary forms have been described (Anil 2007 , Kucukkurt et al . 2016 ). It is a rare disease in humans, and men are diagnosed twice as frequently as women (Pham & Mahindra 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Solitary osseous plasmacytomas in dogs: 13 cases (2004–2019)

Reising

Donnelly

Flesner

et al. 2021

J of Small Animal Practice

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To further characterise solitary osseous plasmacytoma in dogs, an extremely rare disease.To describe diagnosis, disease progression and treatment outcomes in dogs with solitary osseous plasmacytoma.Materials and MethOds: Retrospective review of dogs with solitary osseous plasmacytomas that were diagnosed and treated at a single institution from 2005 to 2019. Kaplan-Meier single group survival analysis was used to estimate median survival time and progression-free interval.results: Thirteen dogs met the inclusion criteria for the study, and of those, 11 were treated. The median age at diagnosis was 8 years (range 4 to 11). Most solitary osseous plasmacytomas occurred in the vertebrae (n=8). Other sites included the maxilla (n=2), the mandible (n=1), the tibia (n=1) and the carpus (n=1). The median survival time for all dogs with solitary osseous plasmacytoma was 912 days (range 5 to 2179), and the progression-free interval for treated dogs was 310 days (range 22 to 2179). Most dogs were treated with radiation therapy (n=10) with nine of 10 receiving a definitive, daily fractionated protocol and with five of ten having had neoadjuvant surgery. Seven dogs received chemotherapy, which was initiated after progressive disease in five dogs. The median survival time for dogs that completed radiation therapy (n=9) was 1166 days (range 545 to 2179). While five dogs developed lesions at other sites, no dogs progressed to multiple myeloma. clinical significance: Canine solitary osseous plasmacytomas can be managed long term with appropriate local therapy. This observation reflects the biologic behaviour observed in humans.

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Solitary plasmacytoma of the mandible: report of two cases

Cited by 6 publications

References 9 publications

Solitary plasmacytoma of maxillofacial bones: correlation of CT features with pathological findings

Solitary plasmacytoma of maxillofacial bones: correlation of CT features with pathological findings

Solitary plasmacytoma masquerading as a benign lesion

Solitary osseous plasmacytomas in dogs: 13 cases (2004–2019)

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