Solitary plasmacytoma of the proximal tibia in an adolescent

Abstract

This is the case report of a 14-year young female who was diagnosed with solitary bone plasmacytoma (SBP) of proximal tibia and was treated by local involved field radiotherapy. We present the clinical, radiological and pathological findings of the case and review of the available treatment options and prognosis of this rare site presentation of plasmacytoma in an adolescent female.

Solitary plasmacytoma of bone involving spine in a 12-year-old boy: Report of a rare case and review of literature

“…[2] SP has been classified into two types: (1) osseous (2) nonosseous primary lesions. SPB is a localized plasma cell neoplasm that most commonly presents as an expansile lytic mass mainly localized within the axial skeleton.…”

“…It has a male/female ratio of 2:1, median age of 55 years (about 10 years younger than patients with MM). [2]…”

“…Extensive literature search revealed that the youngest cases reported till now of SPB are of 14 years of age [Table 1]. [2456789] Extramedullary plasmacytoma and multiple plasmacytomas have been reported at very young age as low as 8 years. [1011] However, to the best of our knowledge, this is probably the youngest case of “solitary” osseous plasmacytoma reported in literature.…”

“…Therefore, antiangiogenic compounds such as thalidomide, vascular endothelial growth factor inhibitors, and proteasome inhibitors have been proposed to be useful in this disease. [2]…”

“…[1] SPB presents more commonly in elderly individuals with a median age of 55 years and predominantly affects the axial skeleton, especially the vertebrae, ribs, and pelvis. [2] SPB in young individuals has been very rarely reported. Here, we present a 12-year-old boy who presented with backache and lytic lesion in L5 vertebra which was initially misdiagnosed as large cell lymphoma but finally turned out to be solitary plasmacytoma.…”