Solitary plasmacytoma of the skull base: A case report and literature review

mansouri, Hanane; elouaouch, Sofia; el youssi, Zahira; guerrouaz, Mohammed Amine; moukhlissi, Mohamed; berhili, Soufiane; mezouar, Loubna

doi:10.1016/j.radcr.2023.08.027

Radiology Case Reports

2023

DOI: 10.1016/j.radcr.2023.08.027

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Solitary plasmacytoma of the skull base: A case report and literature review

Hanane mansouri,

Sofia elouaouch,

Zahira el youssi

et al.

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2024

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Cited by 3 publications

References 29 publications

(41 reference statements)

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Sphenoid plasmacytoma as initial presentation of multiple myeloma—case report

Chadli,

Oudrhiri,

Maamar

et al. 2024

Journal of Surgical Case Reports

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Plasmacytoma is a rare plasma cell neoplasm. Whether solitary or associated with multiple myeloma (MM), it rarely involves the skull base, particularly the sphenoid bone. We present a unique case of sphenoid bone plasmacytoma secondary to MM, highlighting diagnostic and therapeutic challenges. A 56-year-old female presented with headaches, vomiting, epistaxis, and cranial nerve deficits. Cerebral imaging revealed a 65-mm tumor infiltrating the sphenoid bone and adjacent structures. Subtotal resection was performed using an endoscopic nasal approach. Histopathology revealed plasmacytoma, and diagnostic workup confirmed MM. By the end of biological exploration, relapse of the sphenoid plasmacytoma was observed, and the patient was successfully treated with radiotherapy, immunochemotherapy, and autologous stem cell transplantation. After 18-month follow-up, sustained complete remission was confirmed. Although rare, the diagnosis of plasmacytoma should be considered in cases of skull base tumors. This localization is highly predictive of MM, warranting comprehensive investigations to initiate prompt and adequate management.

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Sphenoid plasmacytoma as initial presentation of multiple myeloma—case report

Chadli,

Oudrhiri,

Maamar

et al. 2024

Journal of Surgical Case Reports

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Solitary Plasmacytoma of the Sphenoid Bone: A Case Report and Literature Review

刘

2024

ACM

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Uncommon Presentation of Solitary Plasmacytoma in the Nasal Cavity: Diagnostic and Therapeutic Challenges

Guerrouaz,

Tahri,

Mansouri

et al. 2024

Cureus

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Extramedullary solitary plasmacytoma (SP) is an uncommon tumor and is even rare in the head and neck locations. Here, we report the case of an 82-year-old man admitted to our department for the management of nasal cavity SP. Radiological investigation showed a locally advanced tumor making the patient a noncandidate for surgery. The patient had undergone radiotherapy alone to a total dose of 50 Gy, with 2 Gy per fraction five days a week. After a follow-up of nine months, the tumor recurred, and the patient was managed in the internal medicine department. He received palliative chemotherapy with the cyclophosphamide, dexamethasone, and thalidomide protocol which resulted in a good response. This case illustrates the diagnostic challenges and treatment complexities of SP, particularly in rare locations such as the nasal cavity.

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Solitary plasmacytoma of the skull base: A case report and literature review

Cited by 3 publications

References 29 publications

Sphenoid plasmacytoma as initial presentation of multiple myeloma—case report

Sphenoid plasmacytoma as initial presentation of multiple myeloma—case report

Solitary Plasmacytoma of the Sphenoid Bone: A Case Report and Literature Review

Uncommon Presentation of Solitary Plasmacytoma in the Nasal Cavity: Diagnostic and Therapeutic Challenges

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