Solitary pulmonary adenofibroma in a middle-aged man with bladder cancer

Al-Amer, Mohammad; Abdeen, Yazan; Shaaban, Hamid; Alderink, Carlisle

doi:10.4103/lungindia.lungindia_167_17

Cited by 7 publications

(1 citation statement)

References 11 publications

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“…For predilection sites, the tumors were located slightly more in the left lung than in the right lung, with no significant difference between the upper and lower lobes. Most PAFs were asymptomatic and detected by physical examination, while some can presented with cough (14,16,20), chest pain (12,13,20) and breathlessness (13,16,20). PAF radiographically presented as a solitary, well-circumscribed solid nodule on the peripheral lung, consistent with the features of benign tumors.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Adenofibroma: Clinicopathological and Genetic Analysis of 7 Cases With Literature Review

et al. 2021

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IntroductionPulmonary adenofibroma (PAF), characterized by biphasic differentiation composed of gland-like space lined by respiratory epithelium and stromal spindle cells, is a rare benign tumor of the lung. PAF was reported infrequently and inconsistently with diagnostic criteria and withstood higher risk of misdiagnosis as solitary fibrous tumors (SFTs) due to their morphological resemblance. In this study, we report seven cases of PAF with gene sequencing results and summarize the data of previous literature.Materials and MethodsSeven cases of PAF with surgically resection samples were collected from Pathology department of West China Hospital, Sichuan University between 2009 to 2020. Immunohistochemical studies were performed in all cases and 3 cases underwent a 425-gene panel next-generation sequencing (NGS).ResultsFive female and two male patients were included in this study, with an average age of 51 years. All the patients were asymptomatic, and the lesion was identified on routine chest radiography. The tumor size measured by computed tomography (CT) ranged from 0.5 to 2.7 cm. Gland-like structures were mostly positive for glandular epithelium markers. The spindle cells in stroma expressed Desmin, SMA, ER and PR in 3 of 7 cases. No well-recognized molecular abnormalities can be identified by NGS in the 3 cases. To date, all the patients are alive, with no evidence of recurrence and metastasis.ConclusionPAF is a unique benign pulmonary tumor with low incidence. Biphasic morphology, IHC stains along with molecular detection is of great significance to make a clear diagnosis.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Adenofibroma: Clinicopathological and Genetic Analysis of 7 Cases With Literature Review

et al. 2021

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Uncommon Tumors of the Lung

Moran,

de Groot,

Truong

et al. 2023

The Thorax

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Pulmonary Adenofibromas

Lindholm

Sansano-Valero

Rodriguez

et al. 2020

American Journal of Surgical Pathology

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Thirteen cases of primary pulmonary adenofibromas are presented. The patients are 8 women and 5 men between the ages of 41 and 73 years (average: 57 y). The patients presented with nonspecific symptomatology or their tumor was identified during routine chest films. A wedge resection was performed in all cases with lymph node sampling. Grossly, the tumors varied in size from 1 to 2.5 cm in greatest dimension. The entire tumor was histologically evaluated in all cases. All the tumors shared similar histologic features namely leaf-like/phyllodes-like growth patterns with varying areas of sclerosis, focal inflammation, and entrapped epithelium. A wide panel of immunohistochemical studies was performed including epithelial, neural, muscle, and vascular markers, all of which showed negative staining. The tumors were positive only for vimentin in the stroma and keratin in the entrapped epithelium. Further evaluation in 6 cases using in situ hybridization for the solitary fibrous tumor was performed and was negative. Clinical follow-up in all the patients showed no evidence of recurrence or metastatic disease, during a period of 12 to 36 months. The current cases highlight the unusual occurrence of pulmonary adenofibromas and the importance of separating these tumors from other tumors that may have the potential to recur or metastasize. The use of proper immunohistochemical stains/molecular analysis aids in the proper classification of these tumors.

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Solitary pulmonary adenofibroma in a middle-aged man with bladder cancer

Cited by 7 publications

References 11 publications

Pulmonary Adenofibroma: Clinicopathological and Genetic Analysis of 7 Cases With Literature Review

Pulmonary Adenofibroma: Clinicopathological and Genetic Analysis of 7 Cases With Literature Review

Uncommon Tumors of the Lung

Pulmonary Adenofibromas

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