Solitary Rectal Ulcer Syndrome Mimicking Perianal Crohn's Disease

Powell, Charleston; Lawson, Jessica A; Lindholm, Phillip C

doi:10.7759/cureus.23733

Cited by 4 publications

(1 citation statement)

References 8 publications

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“… 1 The incidence of SRUS is reported to be around 1 case per 100 000 persons every year, but it is believed to be underreported. 2 , 3 The symptoms include a sanguineous rectal discharge, the passage of mucus, and an uncomfortable feeling of inadequate evacuation of stool. 4 It has been reported that any injury in the mucous lining of rectum and localized ischemia are causes.…”

Section: Introductionmentioning

confidence: 99%

Argon plasma coagulation: an effective treatment for solitary rectal ulcer syndrome

Shahid,

Hinna,

Haider

et al. 2024

Ann Saudi Med

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BACKGROUND: Solitary rectal ulcer syndrome (SRUS) is a very rare benign defecation disorder characterized by distinct clinical features and histological findings. Conventional measures are often shown to be ineffective for the treatment of ulcers. Argon plasma coagulation (APC) has recently been shown to be an effective treatment method for SRUS that is refractory to conventional therapy. OBJECTIVES: Determine the efficacy of APC treatment for patients suffering from SRUS. DESIGN: Prospective, single center SETTINGS: Gastroenterology department at a military hospital in Pakistan. PATIENTS AND METHODS: This prospective study included patients with symptoms of rectal bleeding diagnosed with SRUS. Patients were recruited on the basis of clinical, sigmoidoscopic, and histological findings from September 2022 to March 2023. All patients had received conventional treatment initially and were assessed for persistence of symptoms. APC was performed only for those patients who were refractory to standard treatment. MAIN OUTCOME MEASURES: Effectiveness of APC for resistant SRUS. SAMPLE SIZE: 99 patients. RESULTS: The 99 patients diagnosed with SRUS had a median (minimum-maximum) age of patients was 20 (9–41) years. All the patients had undergone conventional treatment, which included the use of laxatives, drinking plenty of water and practicing biofeedback. After this standard treatment, 19 patients (19.19%) recovered fully. However, the remaining 80 patients did not show improvement and underwent APC sessions, out of which 61 patients (76.3%) achieved complete healing of ulcers, while the remaining 19 (23.8%) had no improvement at all. None of the patients reported post session complications. CONCLUSION: APC is an effective therapy with very promising results for rectal ulcer hemorrhage. It also helps with ulcer healing and alleviates clinical symptoms. However, further controlled investigations are required to consolidate the use of APC in SRUS patients. LIMITATIONS: Single centered

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Section: Introductionmentioning

confidence: 99%

Argon plasma coagulation: an effective treatment for solitary rectal ulcer syndrome

Shahid,

Hinna,

Haider

et al. 2024

Ann Saudi Med

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How to assess and manage Crohn’s disease exacerbations in the emergency department

et al. 2023

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Treatment of refractory ulcers of the rectum by autologous stem-cell transplantation

Bagnenko,

Morozov,

Nemkov

et al. 2024

VESTNIK KHIRURGII IMENI I.I.GREKOVA

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The OBJECTIVE was to improve the quality of diagnosis and the effectiveness of treatment of refractory ulcers of the rectum. METHODS AND MATERIALS. We analyzed clinical and biochemical parameters in 39 patients with previously diagnosed solitary ulcers of the rectum. It was proved that in 18 patients, ulceration in the rectum was caused by an autoimmune process, according to the type of Crohn’s disease. The obtained data made it possible to substantiate and apply a new method of treating rectal ulcers – local bone marrow stem cell transplantation. RESULTS. All patients had pain, stool returned to normal, and ulcerative defects were noted to heal. CONCLUSION. Bone marrow stem cell transplantation differs fundamentally in its mechanism of action from known methods of treating rectal ulcers. The method has shown high efficiency and a good safety profile.

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Solitary Rectal Ulcer Syndrome Mimicking Perianal Crohn's Disease

Cited by 4 publications

References 8 publications

Argon plasma coagulation: an effective treatment for solitary rectal ulcer syndrome

Argon plasma coagulation: an effective treatment for solitary rectal ulcer syndrome

How to assess and manage Crohn’s disease exacerbations in the emergency department

Treatment of refractory ulcers of the rectum by autologous stem-cell transplantation

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