Solitary Splenic Metastasis of an Adenocarcinoma of the Ovaries

Max, Leslie D.; Stastny, Janet F.; Frable, William J.

doi:10.1159/000291963

Cited by 9 publications

(9 citation statements)

References 6 publications

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“…Searching the literature database (PubMed, Embase, Medscape) using the criteria of recurrence, solitary, splenic, ovarian cancer and tubal cancer and the references of retrieved articles, we found 35 cases of splenectomy for recurrent TOC (table 1) [5,6,8,26,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44]. Splenectomy was mainly part of secondary cytoreductive surgery and only in one case of tertiary cytoreduction [43].…”

Section: Discussionmentioning

confidence: 99%

“…Concerning tumor spread at primary diagnosis, advanced disease (FIGO Stage III-IV) was observed in 20 (57.1%) cases [6,27,32,34,35,36,37,38,40,41,42,45,] whereas early disease (FIGO Stage I-II) was observed in 9 (25.7%) [5,8,31,33,39,43,44] (unknown in 6 patients). Most cases of spleen recurrence were diagnosed by CT findings or elevated levels of serum CA125.…”

Section: Discussionmentioning

confidence: 99%

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Laparoscopic Splenectomy as Quaternary Cytoreduction for Isolated Parenchymal Splenic Recurrence of Epitelial Tubo-Ovarian Cancer: Report of a Case and Literature Review

Sorbi¹,

Prosperi²,

Villanucci³

et al. 2015

Gynecol Obstet Invest

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Isolated parenchymal splenic lesions are very rare and may occur as recurrences in the form of epithelial tubo-ovarian cancer (ETOC). We report a case of solitary parenchymal splenic recurrence of ETOC, which developed 50 months after the initial treatment. A 66-year-old woman underwent laparotomic primary cytoreduction in 2008. After platinum-based chemotherapy, she developed recurrences; thus, she underwent secondary and tertiary cytoreduction in 2011 and 2012 respectively. In April 2013, CT scan documented a solitary parenchymal splenic lesion and it was confirmed by FDG PET/CT. She underwent quaternary cytoreduction by laparoscopic splenectomy. Histopathological evaluation revealed metastatic parenchymal disease consistent with recurrent ETOC. She was alive and disease-free for ten months since splenectomy. In literature there are 35 cases of isolated spleen parenchymal metastasis of ETOC and our report is the first case of laparoscopic splenectomy in the setting of quaternary cytoreduction. Laparoscopic splenectomy as quaternary cytoreduction is safe and feasible and could be congruent to the well-established experiences already reported for the primary, secondary or even tertiary cytoreduction where the absence of residual disease has been translated in a significant survival benefit.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Laparoscopic Splenectomy as Quaternary Cytoreduction for Isolated Parenchymal Splenic Recurrence of Epitelial Tubo-Ovarian Cancer: Report of a Case and Literature Review

Sorbi¹,

Prosperi²,

Villanucci³

et al. 2015

Gynecol Obstet Invest

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“…Based on our evaluation, only 22 cases fulfi lled the criteria of "recurrence," "solitary," and "parenchymal." [5][6][7][8][9][10][11][12][13][14][15][16][17][18] and these are summarized in Table 1. Most of the patients had stage III disease (FIGO classifi cation) and all underwent optimal tumor debulking, defi ned as the diameter of the largest residual tumor nodule measuring <2 cm at the end of the surgical procedure.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, further studies are necessary to evaluate the exact role of this approach. 8 1 Ic Chemotherapy 30 Chemotherapy 6 NED Balat 9 1 IIIc CTX+CDDP 66 CBDCA 6 AWD Kobayashi 10 1 III CDDP+epirubicin 24 Taxol+CDDP NA Klingler 11 1 III Chemotherapy 24 NA 6 NED Gemignani 12 6 III CTX+CDDP/CBDCA 28-88 Taxol+CBDCA/CDDP 6-65 NED Tamoxifen (1 case) Lauro 13 1 I c CTX+radiotherapy 180 CBDCA+CTX 96 NED Yano 14 1 IIIc NA 36 NA NA Koh 15 1 N A N o 1 2 Taxol+CBDCA 24 AWD Tserkezoglou 16 1 IIIb CDDP 24 CBDCA 20 NED Otrock 17 1 IIa Paclitaxel+CBDCA 84 Paclitaxel+CBDCA 11 NED Furukawa 18 1 …”

Section: Discussionmentioning

confidence: 99%

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Solitary splenic metastasis of ovarian carcinoma: Report of two cases

et al. 2008

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Capsular splenic metastasis from ovarian cancer, which is associated with peritoneal spread, is not uncommon. Conversely, solitary involvement of the splenic parenchymal is unusual, and secondary debulking may improve the prognosis if there is no sign of residual disease. Thus, splenectomy is indicated for this type of isolated splenic metastasis. We report two cases of successful splenectomy for solitary splenic metastasis of ovarian carcinoma and review the relevant literature.

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Solitary splenic metastasis of ovarian cancer

Furukawa

2006

Arch Gynecol Obstet

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This report presents a patient in whom a solitary splenic metastasis was detected 9 years after diagnosis of stage Ic ovarian cancer. The patient was a 59-year-old woman who was diagnosed with stage Ic ovarian serous cystadenocarcinoma in 1992, underwent postoperative chemotherapy, and exhibited no signs of recurrence in terms of clinical symptoms, markers and imaging findings. However, in 2001, a mass was detected in the upper left abdominal region. Magnetic resonance imaging (MRI) suggested a malignant splenic tumor and CA125 levels were elevated at 485 U/ml. The patient underwent a splenectomy and microscopy confirmed the splenic tumor to be of the same histological type as the ovarian cancer. After the splenectomy, CA125 levels decreased markedly and six courses of paclitaxel-carboplatin were administered. At present (60 months post splenectomy), the patient remains disease-free.

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Solitary Splenic Metastasis of an Adenocarcinoma of the Ovaries

Cited by 9 publications

References 6 publications

Laparoscopic Splenectomy as Quaternary Cytoreduction for Isolated Parenchymal Splenic Recurrence of Epitelial Tubo-Ovarian Cancer: Report of a Case and Literature Review

Laparoscopic Splenectomy as Quaternary Cytoreduction for Isolated Parenchymal Splenic Recurrence of Epitelial Tubo-Ovarian Cancer: Report of a Case and Literature Review

Solitary splenic metastasis of ovarian carcinoma: Report of two cases

Solitary splenic metastasis of ovarian cancer

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