Solitary squamous cell papilloma of the lung in a 40‐year‐old woman with recurrent laryngeal papillomatosis

Abstract

A rare case of recurrent respiratory papillomatosis (RRP) is reported with a review of the literature. A 40-year-old Japanese woman had suffered from RRP since 1 year of age. She developed a pulmonary squamous papilloma with a thin-walled cavity, which was suspected as being lung carcinoma. The trachea and bronchi around the tumor were intact, and no malignant transformation was present. Two types of human papillomavirus, 6 and 16, were detected, both in the laryngeal and pulmonary papillomas by in situ hybridization and the polymerase chain reaction method. To date, only 40 cases of juvenile laryngeal papilloma with pulmonary involvement have been reported in the English literature.

Lung involvement in juvenile onset recurrent respiratory papillomatosis: A systematic review of the literature

“…Recurrent respiratory papillomatosis can, however, be protracted by the need for recurrent surgical interventions to avoid airway obstruction and can extend below the vocal cords, sometimes as far as the main stem bronchi; cases of parenchymal lung involvement have been described (recently reviewed by Harada et al [1]). In addition, a number of cases of malignant transformation either at the laryngeal [2,3], bronchial [4], or pulmonary level [5] have been reported.…”

Pulmonary Inverted Schneiderian Papilloma Causing High Serum Levels of Carcinoembryonic Antigen and Squamous Cell Carcinoma-Associated Antigen: Report of a Case

“…Harada et al reported the association of squamous cell carcinoma in 19 of 40 patients with bronchopulmonary squamous cell papilloma. 1 Inverted Schneiderian papilloma is reported to be related to the human papilloma virus (HPV) infection. Identifi cation and subtyping of HPV in the specimen may predict recurrence of the disease.…”

“…3 Inverted Schneiderian papilloma of the lung is sometimes associated with pulmonary squamous cell carcinoma. 1 We report the case of a large pulmonary Schneiderian papilloma causing elevated serum tumor marker levels in a patient without any evidence of lung cancer.…”

“…This disease sometimes involves the lower respiratory tract, including the trachea, bronchi, and lungs. 1 Papillomas arise only in a lung without upper airway disease, and are called "solitary squamous cell papilloma of the lung" 1 or "solitary pulmonary papillomas." 2 Multiple pulmonary papillomas have also been described.…”

Pulmonary spread of laryngeal papillomatosis: radiological findings

“…3,4 The trachea is the most often involved, 4 whereas extension into the distal bronchi, bronchioles, and lung parenchyma is rare-involvement of the lung parenchyma, for example, occurs in fewer than 1%-7% of cases. [4][5][6][7][8][9] Although a literature search found reports of laryngeal papillomas with lung parenchymal involvement, [4][5][6][7][8][9][10][11][12][13][14] there were few reports describing findings of computed tomography (CT) scans of this condition. 9,15,16 In the present report, we offer the results of chest radiography including CT in a case of pulmonary spread of laryngeal papillomatosis after a period of 6 years.…”