Solitary submucous neurofibroma of the mandible: review of the literature and report of a rare case

Depprich, Rita; Singh, Daman D.; Reinecke, Petra; Kübler, Norbert R.; Handschel, Jörg

doi:10.1186/1746-160x-5-24

Cited by 39 publications

(41 citation statements)

References 20 publications

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“…Although oral neurofibroma can occur within any site, the most frequent location is the tongue. It also tends to affect patients at a mean of 31.2 years of age [10]. Oral myofibroma, which may also occur in adults, commonly affects infants [11].…”

Section: Discussionmentioning

confidence: 99%

“…Schwannoma, neurofibroma, myofibroma, and lipoma consist of smooth-surfaced, slow-growing, asymptomatic masses of variable size [9][10][11][12], representing the clinical feature of the current case. The peak of incidence in schwannoma commonly occurs between the third and sixth decades of life and tends to show a predilection for the palate [9].…”

Section: Discussionmentioning

confidence: 99%

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Desmoplastic Fibroblastoma (Collagenous Fibroma): A Case Identified in the Buccal Mucosa

Sousa

Caldeira

Grossmann

et al. 2011

Head and Neck Pathol

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Desmoplastic fibroblastoma is a rare, benign, soft tissue tumor affecting mainly the subcutaneous and muscle tissue. Only five cases identified in the oral cavity have been reported in prior literature. This article presents a case report of a 56-year-old man, with no previous history of trauma, who presented a slow-growing mass in the buccal mucosa. Histopathology and immunohistochemistry staining studies were performed, and a diagnosis of the desmoplastic fibroblastoma was made. The patient has been disease-free for one year.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Desmoplastic Fibroblastoma (Collagenous Fibroma): A Case Identified in the Buccal Mucosa

Sousa

Caldeira

Grossmann

et al. 2011

Head and Neck Pathol

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“…Neurofibromas are most commonly lesions of the skin, and in general population, they rarely affect the oral cavity [6,7]. However, their presence within the oral cavity is not uncommon in association with NF1 [8].…”

Section: Introductionmentioning

confidence: 98%

Oral soft tissue alterations in patients with neurofibromatosis

et al. 2011

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Our aim was to characterize the type and frequency of oral soft tissue alterations in neurofibromatosis. A total of 103 patients with neurofibromatosis 1 (NF1) and three patients with neurofibromatosis 2 (NF2) were clinically evaluated for their oral soft tissue alterations. Disturbing growths were removed from nine patients with NF1 and from one patient with NF2. The specimens were analyzed using routine histological methods and with immunohistochemistry using antibodies to S100, type IV collagen, CD34, neurofilament, and neuron-specific tubulin (TUBB3). Alterations including oral tumors, overgrowths of gingival soft tissue, and enlarged papillae of the tongue were discovered in 74% of NF1 patients. The results showed that three tumors clinically classified as plexiform neurofibromas and five out of six discrete mucosal tumors displayed histology and immunohistology consistent with that of neurofibroma. The histology of one palatal lesion resembled that of a scar, and the lesion removed from the patient with NF2 was classified as an amyloid tumor. To conclude, oral soft tissue growths are common findings in NF1, but most lesions do not require treatment and the patients may even not be aware of these alterations. Collagen IV, S100, and CD34 are useful biomarkers in the analysis of NF1-related oral soft tissue tumors. The clinicians should recognize that oral soft tissue alterations are relatively common in NF1. Some of the growths are disturbing, and plexiform neurofibromas may bear a risk of malignant transformation.

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“…In the head and neck region, solitary neurofibromas are commonly observed to be associated with the 5th and 7th cranial nerves. Oral cavity sites, including tongue, buccal mucosa, and lips, are more affected [2,[5][6][7]. The deep lesions typically present as a facial mass.…”

Section: Discussionmentioning

confidence: 98%

“…Unlike Schwannoma, which is a benign encapsulated neoplasm that arises within a nerve and grows eccentrically without infiltrating the nerve, neurofibroma is a relatively circumscribed but nonencapsulated tumor. Neurofibromas may present either as solitary lesions or part of the generalized syndrome of NF-1 of the skin [2]. The etiology of solitary neurofibroma is still unknown.…”

Section: Discussionmentioning

confidence: 99%