SOLITARY T-CELL HEPATIC LYMPHOMA WITH LARGE GRANULAR LYMPHOCYTE MORPHOLOGY IN A CAPTIVE CHEETAH (ACINONYX JUBATUS)

Abstract

A 13-yr-old male cheetah (Acinonyx jubatus) presented for an acute history of lateral recumbency and anorexia. Upon physical examination under general anesthesia, severe icterus was noted. A serum biochemical profile confirmed markedly elevated total bilirubin and alanine transaminase. Based on ultrasound-guided liver aspirates and cytology, a presumptive diagnosis of large granular lymphocyte hepatic lymphoma was reached. Abdominal and thoracic radiographs did not assist in reaching an antemortem diagnosis. Postmortem examination and histopathology provided a definitive diagnosis of hepatic lymphoma with acute massive hepatocelluar necrosis and hemorrhage, as well as concurrent lesions of gastric ulcers, ulcerative and sclerosing enteritis, myocardial hypertrophy, and splenic myelolipomas. Immunohistochemistry of the liver yielded CD-3 positive and CD-20 negative results, confirming lymphocytes of a T-cell lineage. Due to concern for possible retrovirus-associated disease, enzyme-linked immunosorbent assays for feline leukemia virus and feline immunodeficiency virus were performed retrospectively on a banked serum sample and yielded negative results, thus diminishing concern for the male conspecific housed in the same exhibit.

Clinicopathologic and immunophenotypic features in dogs with presumptive large granular lymphocyte leukaemia

“…Large granular lymphocyte leukaemia (LGLL) has been reported in a wide range of species, including humans, dogs, domestic cats, horses, rats, a cheetah and a ferret 1–9 . In human reports from North America and Europe, LGLL comprises 2%–5% of chronic lymphoproliferative disorders 10 .…”

Intestinal T-cell lymphoma in a coati (Nasua nasua) – Short communication

“…Multicentric lymphoma is the most common anatomic form of canine, feline and equine lymphoma, followed by extranodal lymphoma in dogs, alimentary and mediastinal lymphoma in cats, and intestinal and cutaneous lymphoma in horses (Valli et al, 2000;Vezzali et al, 2009;Durham et al, 2012). Occasional cases of lymphoma have been described in wild animals, such as intestinal lymphoma in a sea lion (Colegrove et al, 2010), multicentric lymphoma in a raccoon (Hamir et al, 1996), hepatic lymphoma in a cheetah (Lindemann et al, 2015), enteric lymphoma in a harbour seal (Malberg et al, 2017), and cutaneous lymphoma in Tasmanian devils (Peck et al, 2019). Alimentary lymphoma can be single or multiple (Frank et al, 2007) and it occurs mainly in the small intestine, followed by the large intestine and stomach (Kaneko et al, 2009;Moore et al, 2012).…”