Solubilisation capacity of Brij surfactants

Ribeiro, Maria Elenir Nobre Pinho; Moura, Carolina L. de; Vieira, Mariano G.S.; Gramosa, Nilce V.; Chaibundit, Chiraphon; Mattos, Marcos Carlos de; Attwood, David; Yeates, Stephen G.; Nixon, S. Keith; Ricardo, Nágila M.P.S.

doi:10.1016/j.ijpharm.2012.07.032

Cited by 47 publications

(22 citation statements)

References 24 publications

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“…Melted griseofulvin was prepared in the DSC using the protocol described in the paper (10 min annealing at 230°C), which assures the recrystallization toward form II and III upon heating. Except a small peak at 1.67 ppm due to water contamination of hygroscopic CDCl 3 , the two spectra are totally identical and perfectly compatible with those already reported in the literature 26. This clearly proves that the melt prepared in the DSC and recrystallizing toward forms II and III is free of any chemical degradation.…”

Section: Discussionsupporting

confidence: 88%

On the Polymorphism of Griseofulvin: Identification of Two Additional Polymorphs

Mahieu

willart

Dudognon

et al. 2013

Journal of Pharmaceutical Sciences

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Section: Discussionsupporting

confidence: 88%

On the Polymorphism of Griseofulvin: Identification of Two Additional Polymorphs

Mahieu

willart

Dudognon

et al. 2013

Journal of Pharmaceutical Sciences

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“…Solubilisation capacity data published by Attwood and Booth [22] to P123 and F127, 3.0 and 2.2 mg g -1 , were similar with our results, considering the standard deviation of samples, using the same method and temperature [22] . As it would be expected from this discussion, the solubilisation capacity of E M P N E M diluted solutions, with hydrophobic P blocks, showed low values when compared with values of other types of copoly(oxyalkylenes) [1,22,24] . However, Lee et al [8] studied the S CP and aqueous stability of copolymers of E M P N E M type, analyzing their HLB (hydrophilic/lipophilic balance), and observed that the solubility of the drug in these nano-colloidal systems do not just depend on hydrophobicity of the block, but also on the length of the hydrophilic block [8] .…”

Section: Solubilisationsupporting

confidence: 61%

“…Values of S CP of the copolymer solutions for griseofulvin were obtained by UV/Visible spectroscopy, and these results are reported in milligrams of solubilized drug per gram of copolymer in solution (S mg.g -1 ), after correction for the solubility of griseofulvin in water (S 0 mg.dL -1 ), S CP = S -S 0, [6,14,22,24] .The values of S 0 for griseofulvin were 1.34 and 1.83 mg.dL -1 at 25 and 37 °C, respectively, similar to those reported by Ribeiro et al [24] , and the values of S CP (mg/g) obtained for F127, P123 and their mixtures, PF 30, 50 and 70, are showed in Figure 5.…”

Section: Solubilisationmentioning

confidence: 99%

Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation

et al. 2015

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Sbstract Pluronics molecules self-assemble in aqueous solution providing a core/shell architecture that improves the solubility of hydrophobic drugs. Binary mixtures of Pluronics  have been studied as drug nanocarriers in order to combine their advantages, like high colloidal stability, small particle size and good solubilisation capacity (S cp ). In this work we studied Pluronics  binary mixture, P123 and F127, as nanocarriers of the hydrophobic drug griseofulvin. P123 (E 21 P 67 E 21 ) shows a relative good S cp , whereas F127 (E 98 P 67 E 98 ) shows a good colloidal stability. According to data, these binary mixtures form stables nano-sized comicelles in aqueous solution. The S cp of the P123/F127 systems at 25 and 37 °C was monitored by UV/Visible spectroscopy, showing good results at both temperatures, as would be expected, since P123/F127 have similar length hydrophobic block. Hydrophobic-dependence and temperature-responsive of the systems were evaluated by CMC, particle size and colloidal stability. Hence, stables P123/F127 comicelles may have potencial as hydrophobic drug delivery.

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“…[8] For example, the Brij surfactants are characterized by long polar heads that even manage to have the same or greater length than the hydrophobic region. [9] The great versatility of TOPO in different scientific and technological fields lies in the unique properties of the P=Og roup, which has free electrons pairs with as trong ability to complexn umerous species. [10] Some studies have reported the use of this compound as an alternative for nanoparticles ynthesis, for controlling and inhibiting the growth morphology.…”

Section: Introductionmentioning

confidence: 99%

Nanoscale Control Over Interfacial Properties in Mixed Reverse Micelles Formulated by Using Sodium 1,4‐bis‐2‐ethylhexylsulfosuccinate and Tri‐n‐octyl Phosphine Oxide Surfactants

Odella¹,

Falcone²,

Silber³

et al. 2016

ChemPhysChem

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The interfacial properties of pure reverse micelles (RMs) are a consequence of the magnitude and nature of noncovalent interactions between confined water and the surfactant polar head. Addition of a second surfactant to form mixed RMs is expected to influence these interactions and thus affect these properties at the nanoscale level. Herein, pure and mixed RMs stabilized by sodium 1,4-bis-2-ethylhexylsulfosuccinate and tri-n-octyl phosphine oxide (TOPO) surfactants in n-heptane were formulated and studied by varying both the water content and the TOPO mole fraction. The microenvironment generated was sensed by following the solvatochromic behavior of the 1-methyl-8-oxyquinolinium betaine probe and (31) P NMR spectroscopy. The results reveal unique properties of mixed RMs and we give experimental evidence that free water can be detected in the polar core of the mixed RMs at very low water content. We anticipate that these findings will have an impact on the use of such media as nanoreactors for many types of chemical reactions, such as enzymatic reactions and nanoparticle synthesis.

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Solubilisation capacity of Brij surfactants

Cited by 47 publications

References 24 publications

On the Polymorphism of Griseofulvin: Identification of Two Additional Polymorphs

On the Polymorphism of Griseofulvin: Identification of Two Additional Polymorphs

Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation

Nanoscale Control Over Interfacial Properties in Mixed Reverse Micelles Formulated by Using Sodium 1,4‐bis‐2‐ethylhexylsulfosuccinate and Tri‐n‐octyl Phosphine Oxide Surfactants

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