Solubilities of Flutamide, Dutasteride, and Finasteride as Antiandrogenic Agents, in Supercritical Carbon Dioxide: Measurement and Correlation

Abstract

The solubilities of flutamide, dutasteride, and finasteride in supercritical carbon dioxide were investigated at temperatures of (308.0, 318.0, 328.0, 338.0, and 348.0) K and various pressures in the range of (12.1 to 35.5) MPa. The measured results were then correlated using semiempirical equations presented by Chrastil and Bartle. With optimally fitted parameters, the average absolute relative deviations (AARD) ranged from 0.122 to 0.260 and from 0.024 to 0.137 for Chrastil and Bartle models, respectively. The heat of drug-CO 2 solvation and that of drug vaporization were approximated in the range of (-17.4 to -16.8) kJ • mol -1 and (73.7 to 90.1) kJ • mol -1 , respectively.

New Experimental Data and Modeling of the Solubility of Compounds in Supercritical Carbon Dioxide

“…In order to compare the accuracy of these models, the available solubility data (in mole fraction) of 54 different kinds of compounds have been collected from the literature (including 1155 data points). ,,− The details of compounds (names and formulas) and their references are listed in Table . The details of the solubility data (temperature, pressure, mole fraction solubility of the solutes, and number of experimental data points) are presented in Table .…”

Determination and correlation of solubilities of famotidine in water+co-solvent mixed solvents

“…The Chrastil model [39] has been widely been used to correlate experimental solubility data without co-solvents in supercritical carbon dioxide [40][41][42]. González et al proposed a modified Chrastil model which takes the co-solvent contribution to the solubility into account [24].…”

Solubility of Mesquite Gum in Supercritical Carbon Dioxide

“…Empirical and semiempirical correlations based on the density of the pure SC-CO 2 are widely used for the correlation of solid-SCF equilibrium mainly due to their simplicity and easy application. In the present study, the experimental data were correlated using the Bartle et al model 14 and M endez-Santiago and Teja model. 15 Bartle and co-workers 16 proposed a simple density-based semiempirical model to correlate the solubility of solids in SC-CO 2…”