Solubilities of four macrolide antibiotics in supercritical carbon dioxide and their correlations using semi-empirical models

Asiabi, Hamid; Yamini, Yadollah; Latifeh, Farzad; Vatanara, Alireza

doi:10.1016/j.supflu.2015.05.018

Cited by 36 publications

(13 citation statements)

References 39 publications

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“…It can rapidly go deep into the microstructure of shale to dissolve the nonpolar and weakly polar material embedded in shale. Studies have shown that the dissolving capability of SC-CO 2 is closely related to its density, and the density of SC-CO 2 can be changed significantly by changing its pressure and temperature. − The dissolving capability of SC-CO 2 varies greatly between different substances. In general, − SC-CO 2 can extract lipophilic, low-boiling-point components at pressures lower than 10 MPa, e.g., volatile oils, hydrocarbons, esters, lactones, ethers, and epoxides.…”

Section: Characteristics Of Sc-co2mentioning

confidence: 99%

“…Studies have shown that the dissolving capability of SC-CO 2 is closely related to its density, and the density of SC-CO 2 can be changed significantly by changing its pressure and temperature. − The dissolving capability of SC-CO 2 varies greatly between different substances. In general, − SC-CO 2 can extract lipophilic, low-boiling-point components at pressures lower than 10 MPa, e.g., volatile oils, hydrocarbons, esters, lactones, ethers, and epoxides. Substances that introduce strong polar groups (such as −OH and −COOH) cannot be easily extracted by SC-CO 2 .…”

Section: Characteristics Of Sc-co2mentioning

confidence: 99%

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Effect of Supercritical Carbon Dioxide Treatment Time, Pressure, and Temperature on Shale Water Wettability

et al. 2016

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Supercritical carbon dioxide (SC-CO 2 ) fluid can dissolve surface matter on shale and, thus, change the surface properties of shale. To study the influence of SC-CO 2 on the water wettability of shale, shale samples collected from the Longmaxi formation in Sichuan Basin were treated with SC-CO 2 at various time intervals, pressures, and temperatures. The results show that, after SC-CO 2 treatment, the ratio of C and Si in the shale increased, while the ratio of O, Ca, Mg, and H decreased. Water was released from the clay minerals, and the CaCO 3 content decreased in the shale. After SC-CO 2 treatment, the primary pores and fractures in the shale were eroded through dissolution and new pores and fracture structures were developed on the surface microstructure of the shale. As a result, the structure connectivity, which favored the seepage of shale gas, was improved. The results also show that the shale−water contact angles were increased after SC-CO 2 treatment. The treatment time and pressure had a significant influence on the contact angles, but the effect of the treatment temperature on contact angles was not obvious. The change in the contact angles resulted from a reduction of the CaCO 3 content on the shale surface, which decreased the surface hydrophilicity. The shale surface water wettability and the shale surface tension were decreased after SC-CO 2 treatment. This reduces the hindrance function of water in the shale minimal pores and fracture, which is beneficial to CO 2 diffusion into the shale matrix. This promotes CO 2 adsorption capacity in the shale as well as CH 4 desorption from the shale. This study provides a theoretical basis for using SC-CO 2 fluid for efficient shale gas exploitation in the Longmaxi formation of the Sichuan Basin.

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Section: Characteristics Of Sc-co2mentioning

confidence: 99%

Section: Characteristics Of Sc-co2mentioning

confidence: 99%

Effect of Supercritical Carbon Dioxide Treatment Time, Pressure, and Temperature on Shale Water Wettability

et al. 2016

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“…Generally, the solubility of antibiotics or of anti-inflammatory drugs in CO 2 is very low. Indeed, it is the case of nimesulide [4][5][6], gatifloxacin [7], penicillin G [8], penicillin V [9], cefixime trihydrate [10], dexamethasone [11], azithromycin [12], erythromycin [12], clindamycin [12] and clarithromycin [12]. The values of their solubility vary between 10 −7 and 10 −5 (in mole fraction).…”

Section: Introductionmentioning

confidence: 99%

Solubility of cefuroxime axetil in supercritical CO2: Measurement and modeling

Ongkasin

Sauceau

Masmoudi

et al. 2019

The Journal of Supercritical Fluids

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“…Development of SCF processes for fine particle formation is important and is dependent on: “how much measurement of experimental drug’s solubility in SCFs is accurate” and its modeling to assure a suitable process design [ 19 , 20 ]. Solubility data in SCF knowledge and their variation under operating temperature and pressure are considered the first step to assess capabilities of SCF extraction and area criterion to choose a process among the different that exist.…”

Section: Introductionmentioning

confidence: 99%

Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited

Nasri¹

2021

Antibiotics

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Development of processes using green solvents as supercritical fluids (SCFs) depends on the accuracy of modeling and predicting phase equilibrium which is of considerable importance to exploit the use of SCF process at the level of pharmaceutical industries. Solid-Fluid equilibrium modeling is associated to many drawbacks when compressed gas-based models as cubic equations of states (cEoSs) are used. The unavailability of experimental values of solute’s sublimation pressure presents one of the major obstacles to the solubility modeling with this type of models, and thus, its estimation is essential and inevitable. This work is an attempt to address a question regarding “accurate estimated value” of sublimation pressure of two antibiotics Penicillin G (benzyl penicillin) and Penicillin V (phenoxymethyl penicillin). Toward that, first, cEoSs are provided as the thermodynamics modeling framework and fundamental approach. Second, a discussion and a review of some literature results are given. Third, results are invoked to present a criticism analysis that comes from the use of modified form of Peng-Robinson (PR) equation of states. Finally, considerable improvement of modeling results by using a new sublimation pressure is shown.

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Solubilities of four macrolide antibiotics in supercritical carbon dioxide and their correlations using semi-empirical models

Cited by 36 publications

References 39 publications

Effect of Supercritical Carbon Dioxide Treatment Time, Pressure, and Temperature on Shale Water Wettability

Effect of Supercritical Carbon Dioxide Treatment Time, Pressure, and Temperature on Shale Water Wettability

Solubility of cefuroxime axetil in supercritical CO2: Measurement and modeling

Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited

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