Solubility and Dissolution Behavior Analysis of 7-Azaindole in Pure and Binary Mixture Solvents at Temperatures Ranging from 278.15 to 323.15 K

Deng, Zhenmei; Li, Fangzhao; Zhao, Guangjie; Yang, Wenge; Hu, Yonghong

doi:10.1021/acs.jced.0c00128

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…The solubility order of phenol red in protic solvent was methanol > ethanol > n -butanol > n -propanol > isopropanol > water > isobutanol, and the solubility order of phenol red in aprotic solvent was DMF > acetone > acetonitrile > ethyl acetate > methyl acetate. According to the search literature, − the order of polarity and permittivity of the six protic solvents was: water (100) > methanol (76.2) > ethanol (65.4) > n -propanol (61.7) > n -butanol (60.2) > isobutanol (55.2) > isopropanol (54.6). The order of polarity and permittivity of aprotic solvent was acetonitrile (46) > DMF (40.4) > acetone (35.5) > methyl acetate (29) > ethyl acetate (23).…”

Section: Results and Discussionmentioning

confidence: 99%

Solubility Determination and Analysis of Phenol Red in Monosolvent and Binary Mixed Solvent at T = 278.15–323.15 K

Cheng,

Zhang,

Yang

et al. 2023

J. Chem. Eng. Data

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The solubility and thermodynamic characteristics of phenol red were determined by the static equilibrium method combined with HPLC. The equilibrium solubility of phenol red in 12 monosolvents (methanol, ethanol, npropanol, isopropanol, n-butanol, isobutanol, acetonitrile, methyl acetate, ethyl acetate, DMF, water, and acetone) was measured at a temperature range of 278.15−323.15 K and a constant pressure of 101.1 kPa. The results showed that in the experimental temperature range, the solubility of phenol red is positively correlated with the temperature and reached the maximum and minimum values in DMF and isobutanol. Ethanol, acetonitrile, and water were randomly selected to form three groups of binary mixed solvents, the monosolvent with high solubility is used as the cosolvent in the binary mixed solvent, and the solubility data were measured under the same experimental conditions. Interestingly, in all binary mixed solvents, the solubility data of phenol red showed a trend of first increasing and then decreasing with the increase of the proportion of cosolvent. The Buchowski−Ksiazaczak λh model and Apelblat model were used to fit the solubility data of phenol red in monosolvent, and the average root mean square deviation (RMSD) values are 3.8775 × 10 −2 and 4.6592 × 10 −3 . The Jouyban−Acree model, CNIBS/R-K model, and Sun model were used to fit the solubility data of phenol red in binary mixed solvent, and the average RMSD values were 9.4265 × 10 −6 , 5.1215 × 10 −6 , and 9.4265 × 10 −6 . Furthermore, the solvation of phenol red was investigated by the KAT-LSER model. The results showed that the acidity of the hydrogen bond had a significant effect on the solubility, and the contribution rate was 35.5%.

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Section: Results and Discussionmentioning

confidence: 99%

Solubility Determination and Analysis of Phenol Red in Monosolvent and Binary Mixed Solvent at T = 278.15–323.15 K

Cheng,

Zhang,

Yang

et al. 2023

J. Chem. Eng. Data

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“…In the experimental data figures (Figure ), with the increase of temperature, the solubility curves showed crossover phenomenon to varying degrees, indicating that the solubility of TMCA in different solvents was sensitive to temperature changes in different degrees, so the solubility increasing rate was different, and each solubility curve also had different change rules. In terms of the polarity of solvent (water = 100), − methanol (76.2) > ethanol (65.4) > n -propanol (61.7) > n -butanol (60.2) > isobutanol (55.2) > isopropanol (54.6) > acetonitrile (46) > acetone (35.5) > methyl acetate (29) > ethyl acetate (23). The experimental results show that the solubility of TMCA in monosolvents is not completely dependent on the influence of solvent polarity but may also be related to the length of the carbon chain, functional group, and molecular size.…”

Section: Resultsmentioning

confidence: 99%

Measurement and Analysis of Solvent Behavior and Thermodynamic Properties of 3,4,5-Trimethoxycinnamic Acid in Industrial Common Solvents with Different Temperatures (T = 278.15–323.15 K)

et al. 2022

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Herein, the solubility and thermodynamic characterization solubility of 3,4,5-trimethoxycinnamic acid (TMCA) were studied by a static equilibrium method combined with high-performance liquid chromatography (HPLC), which provided a significant reference for crystallization and industrial separation of TMCA. First, the solubility data of TMCA was measured in 11 industrial common solvents and 4 binary mixed solvents at different temperatures (278.15–323.15 K) under atmospheric pressure. The results showed that the solubility of TMCA in the test solvents was positively correlated with temperature. In binary solvents, the increase in the mole fraction of the cosolvent also facilitated the dissolution of TMCA. Then, the monosolvent solubility data obtained in the experiment were fitted by the Buchowski–Ksiazaczak λh model and modified Apelblat model. The binary mixed solvent solubility data obtained in the experiment were fitted by the CNIBS/R–K model, Jouyban–Acree model, and SUN model. Meanwhile, the KAT-LSER model was also used to explore the effect of the solvation of TMCA. Furthermore, as can be seen from differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses, the purity of the sample is without crystal transformation before and after dissolution, indicating that the physical and chemical properties of the TMCA sample are stable in the experimental process, and the experimental data have good accuracy and reliability.

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“…The modified Apelblat model is a semi-empirical equation, which was originally proposed by Apelblat and Manzurola . The model was applied widely and correlated well between the solubility and temperature. − The model can be expressed as shown in eq , where x is the solubility of the solute, and A , B , and C are the parameters. …”

Section: Correlating Modelsmentioning

confidence: 99%

“…The technology of powder X-ray diffraction was employed to judge the phenomenon of crystal transformation. The experimental solubility was correlated by thermodynamic models such as the modified Apelblat model, − λh model − Van′t Hoff model, − and Jouyban Acree–Apelblat model − for predicting the dissolution state in a wider temperature range.…”

Section: Introductionmentioning

confidence: 99%

Solubility Measurement and Model Correlating of 6-Propyl-2-Thiouracil in Four Binary Solvents at 278.15–323.15 K

et al. 2021

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The solubility of 6-propyl-2-thiouracil was determined in DMF + water, DMF + methanol, DMF + ethanol, and DMF + 1-propanol mixture solvents by a gravimetric method in the temperature range from 278.15 to 323.15 K under atmospheric pressure. The results indicated that the solubility of 6-propyl-2thiouracil in the (DMF + methanol) mixture is greater than that in (DMF + ethanol), (DMF + 1-propanol), and (DMF + water) at the same DMF composition and temperature, and that the solubility increased with increase in the mass fraction of DMF in mixture solvents. The modified Apelblat model, λh model, Van′t Hoff model, and Jouyban Acree-Apelblat model were employed to correlate well with the solubility of 6-propyl-2-thiouracil in four binary solvents using values of ARD% and RD, and the four models were considered to be the reliable methods for the solubility prediction of 6-propyl-2-thiouracil.

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Solubility and Dissolution Behavior Analysis of 7-Azaindole in Pure and Binary Mixture Solvents at Temperatures Ranging from 278.15 to 323.15 K

Cited by 9 publications

References 26 publications

Solubility Determination and Analysis of Phenol Red in Monosolvent and Binary Mixed Solvent at T = 278.15–323.15 K

Solubility Determination and Analysis of Phenol Red in Monosolvent and Binary Mixed Solvent at T = 278.15–323.15 K

Measurement and Analysis of Solvent Behavior and Thermodynamic Properties of 3,4,5-Trimethoxycinnamic Acid in Industrial Common Solvents with Different Temperatures (T = 278.15–323.15 K)

Solubility Measurement and Model Correlating of 6-Propyl-2-Thiouracil in Four Binary Solvents at 278.15–323.15 K

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