Solubility and distribution of bicycle derivatives of 1,3-selenazine in pharmaceutically relevant media by saturation shake-flask method

Anti‐proliferative Activities of Thiophenes, Pyrans and PyridinesDerived from 1,3‐Dicarbonyl Compounds

“…[9][10][11][12] In addition, such group of compounds were used as good drugs within the field of pharmaceutical chemistry. [13][14][15][16] It was reported thatseveral studies were on the discovery and development of more efficient pharmaceuticals, pesticides, insecticides, rodenticides, and weed killers by following well studied natural models and biochemical pathways in livingcells. [17,18] In the fields of drug discovery there were some studies were done through the of the structure activity-relationship studies (SAR) for drug design and synthesis of heterocyclic compounds.…”

Solubility Determination of Hydroquinone in Dichloromethane, Trichloromethane and Carbon Tetrachloride by Using the Co-solvent Calibration Method

“…Turbidimetry and nephelometry are also used but they are based on the precipitation of material and, due to the possibility of over-saturation, might be inaccurate [8]. The "saturation shake-flask method" is also widespread but it is time consuming [9][10][11][12][13][14][15][16][17]. The "generator column" method highly facilitates the reaching of solubility equilibrium [18] as the contacting area between the solid material and solvent is very high and the saturation concentration can be measured as usual in chromatography.…”