Solubility and Precipitation of Nicotinic Acid in Supercritical Carbon Dioxide

Rehman, Mahboob; Shekunov, Boris Y.; York, Peter; Colthorpe, Paul

doi:10.1002/jps.1107

Cited by 60 publications

(34 citation statements)

References 20 publications

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“…Controlled production of different polymorphic forms, including new forms, has been demonstrated with this technology by varying the working conditions of temperature, pressure or solution flow rate (5,224,230Y232). The materials produced are usually crystalline and have a low residual solvent content (25,84,230,233). Engineering of hydrates, solvates and amorphous solids by SAS processing has also been reported (36,230).…”

Section: Precipitation Of Small Molecules With Supercritical Antisolvmentioning

confidence: 99%

Particle Engineering for Pulmonary Drug Delivery

et al. 2007

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With the rapidly growing popularity and sophistication of inhalation therapy, there is an increasing demand for tailor-made inhalable drug particles capable of affording the most efficient delivery to the lungs and the most optimal therapeutic outcomes. To cope with this formulation demand, a wide variety of novel particle technologies have emerged over the past decade. The present review is intended to provide a critical account of the current goals and technologies of particle engineering for the development of pulmonary drug delivery systems. These technologies cover traditional micronization and powder blending, controlled solvent crystallization, spray drying, spray freeze drying, particle formation from liquid dispersion systems, supercritical fluid processing and particle coating. The merits and limitations of these technologies are discussed with reference to their applications to specific drug and/or excipient materials. The regulatory requirements applicable to particulate inhalation products are also reviewed briefly.

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Section: Precipitation Of Small Molecules With Supercritical Antisolvmentioning

confidence: 99%

Particle Engineering for Pulmonary Drug Delivery

et al. 2007

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“…Thus, mass transfer is not limited by molecular diffusion or convective phenomena. By using this technique, it is possible to control the size, shape and morphology of the material of interest (44). So in our previous research, precipitation of puerarin or phospholipids by GAS method and their complex by SEDS could be obtained successfully for the first time by the optimization of the experimental conditions (to be published), yet the attempts for preparing PPC with GAS failed.…”

Section: Introductionmentioning

confidence: 98%

Comparative Physicochemical Characterization of Phospholipids Complex of Puerarin Formulated by Conventional and Supercritical Methods

Yang²,

Chen

et al. 2007

Pharm Res

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“…Methods used in the past for the manufacture of drug nanoparticles usually do not allow very accurate control of the particle size, and so broad particle size distributions are obtained. Supercritical antisolvent (SAS) processes have been widely used for the last ten years to precipitate Active Pharmaceutical Ingredients (APIs) (Chattopadhyay& Gupta, 2001;Rehman et al, 2001;Velaga et al, 2002;Yeo & Lee, 2004). Supercritical antisolvent techniques overcome the main drawbacks of conventional techniques, such as the degradation of the active ingredients because of the high profiles of temperatures and tensile stresses reached and the large amount of organic solvent used, resulting in the need to remove the solvent from the final product.…”

Section: Pharmaceuticalsmentioning

confidence: 99%

“…The particle precipitation into micro and nanoparticles has been an active research field for decades (Chattopadhyay & Gupta, 2001;Kalogiannis et al, 2005;Rehman et al, 2001;Reverchon, 1999;Velaga et al, 2002;Yeo&Lee, 2004). The greatest requirement in the application of nanomaterials is its size and morphology control which determine the potential application of the nanoparticles, as their properties vary significantly with size.…”

Section: Introductionmentioning

confidence: 99%