Solubility and preferential solvation of sulfadiazine in methanol+water mixtures at several temperatures

Solubility and preferential solvation of sulfadiazine, sulfamerazine and sulfamethazine in propylene glycol+water mixtures at 298.15K

“…PG is a co-solvent widely used in the design of liquid medicines intended for oral and parenteral administration of drugs [9]. Thus, this work is a continuation of those presented previously in the literature about the solubility of these three sulfonamides in co-solvent mixtures [5][6][7][8].…”

“…These equilibrium times were established by measuring the SDZ concentrations in aqueous media until they became constant. It is important to note that SDZ is the less soluble sulfonamide [5][6][7][8]. After these times the supernatant solutions were filtered (Millipore Corp. Swinnex®-13) at isothermal conditions to ensure that they were free of particulate matter before sampling.…”

“…Although some theoretical and semiempirical models have been developed to predict drug solubilities in co-solvent mixtures, the availability of experimental data is still fundamental for chemical and pharmaceutical scientists [4]. In this way, because the solubility of these three sulfonamides in neat water is too low [1,3], some co-solvent + water mixtures have been evaluated in order to increase their aqueous solubilities [5][6][7][8]. These studies have also been carried out to understand the molecular mechanisms involved in the drug dissolution processes.…”

Measurement, correlation of the solubility and solution thermodynamics of 2-cyanoguanidine in (methanol+water) binary solvent systems from T=(283.15 to 343.15)K

“…However, the solubility of 2-cyanoguanidine in various (methanol + water) mixed solvent systems has not been reported in the literature. In addition, It is necessary to understand the basic thermodynamics [13,14], such as solubility [15], dissolution enthalpy, dissolution entropy, and molar Gibbs free energy in the industrial crystallization process of 2-cyanoguanidine [16,17]. The modified Apelblat model and the semi-empirical Buchowski-Ksiazczak kh model are generally used to investigate the influence of temperature on mole fraction solubility of the solute [18,19].…”

Preferential solvation of somen-alkylp-substituted benzoates in propylene glycol + water cosolvent mixtures

“…Peña et al molar Gibbs energy of mixing for the cosolvent binary mixtures. As it has well been indicated in the literature, this treatment is very important in pharmaceutical sciences to understand the solute-solvent molecular interactions because it allows analysing the local environment around the drug molecules describing the local fraction of the solvent components in the surrounding of the solute (compound 3) [12,13]. The results are expressed in terms of the preferential solvation parameter δx 1,3 of the solute by the cosolvent PG (compound 1) according to the following expression:…”