Solubility and stability of phenytoin sodium when mixed with intravenous solutions

Carmichael, Ronald R.; Mahoney, Charles D.; Jeffrey, Louis P.

doi:10.1093/ajhp/37.1.95

Cited by 4 publications

(2 citation statements)

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“…In most cases, solubility can be increased by altering the pH of a solution. One well-known example is phenytoin sodium, in which the solubility is significantly increased by the addition of sodium hydroxide (NaOH), in order to allow parenteral administration at a desired concentration [ 33 ]. Chemical stability is another crucial factor, as drugs in solution tend to be less stable than in solid dosage forms.…”

Section: Pharmaceutical Considerationsmentioning

confidence: 99%

Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

et al. 2018

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The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes.

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Section: Pharmaceutical Considerationsmentioning

confidence: 99%

Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

et al. 2018

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“…One well known example is phenytoin sodium, where solubility of this acidic barbiturate is tremendously increased by addition of NaOH to phenytoin so as to allow parenteral administration at a desired concentration. (19) Chemical stability is another crucial factor as drugs in solution tend to be less stainless steel and only slightly corrosive on grey cast iron and tool steel alloys. Therefore, methanesulfonate was chosen as preferred counter ion followed by further development.…”

Section: Parenteralmentioning

confidence: 99%

Salts of Therapeutic Agents: Chemical, Physicochemical and Biological Considerations

Gupta¹,

Bhatia²,

Dave³

et al. 2018

Preprint

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Choice of the salts of therapeutic agents or active pharmaceutical ingredients (API) is based on the physicochemical properties of API and the dosage form considerations. The appropriate salt can have positive effect on overall therapeutic and pharmaceutical effects of API. However, the incorrect salt form can negatively affect the overall pharmaceutical outcomes of the API. This review addresses various criteria for choosing appropriate salt form along with the effect of salt forms on API’s pharmaceutical properties. In addition to comprehensive review of the criteria, this review also gives a brief historic perspective of the salt selection process.

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IV Administration of phenytoin

Byerly

Horton

1990

J Gen Intern Med

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Solubility and stability of phenytoin sodium when mixed with intravenous solutions

Cited by 4 publications

References 0 publications

Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

Salts of Therapeutic Agents: Chemical, Physicochemical and Biological Considerations

IV Administration of phenytoin

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