Solubility Behavior of N-Carbobenzoxy-l-2-phenylglycine in 11 Pure and a Binary Ethanol + Water Solvent Systems at 283.15–323.15 K

Abstract

The mole fraction solubility data of N-carboxyphenoxy-L-2-phenylglycine in 11 neat solvents (methanol, water, isopropyl alcohol, ethanol, n-propyl alcohol, methyl acetate, ethyl acetate, acetone, dichloromethane, acetonitrile, and butanone) and a binary solvent mixture of ethanol + water were determined by the static gravimetric method at 283.15–323.15 K. From the solvent effect analysis, the solubility behavior was affected not only by polarity, but also by some other factors such as hydrogen bonding, cohesive energy density, and molecular structure. The solubility data of N-carboxyphenoxy-L-2-phenylglycine were correlated by using the two-dimensional modified Apelblat model and three-dimensional Apelblat–Jouyban–Acree model. The maximum values of root-mean-square deviation and relative average deviation were 100.98 × 10–4 and 20.53%, respectively. The solubility calculated by the two models agreed well with the experimental values.

Solubility and Solvent Effect Analysis of Boc-l-glutamine in Different Solvents at Multiple Temperatures

“…It can be seen from Figure that with the exception of isopropanol, water, acetone, 2-butanone, acetonitrile, and n -pentanol, the solubility behavior of Boc- l -glutamine in different pure solvents is mainly affected by solvent polarity . A monotonous increase in solubility of Boc- l -glutamine with E T (30) was obtained for ethanol, n -propanol, n -butanol, isobutanol, methyl acetate, and ethyl acetate.…”

Solubility and Solvent Effect Analysis of N-Benzyloxycarbonyl-l-tryptophan in 12 Monosolvent Systems at Multiple Temperatures

“…Powder X-ray diffractometer (PANalytical B.V. X’Pert PRO MPD, Netherlands) analysis was performed to determine the existence of polymorph transition or solvate formation of N -benzyloxycarbonyl- l -tryptophan during the solubility measurement process in different solvents. , The sample preparation details are shown in the Supporting Information. PXRD was coupled with an X-ray generator of Cu Ka radiation (1.5406 Å), and the determinations were operated at a scanning rate of 10°/min under a fixed voltage (2θ: 5–60°, voltage: 40 kV, and current: 150 mA).…”

“…Based on the Clausius Clapeyron equation, the modified Apelblat model has become one of the most commonly and widely used models in solubility correlation and prediction, especially in engineering applications. Although expressed by a simple mathematical equation, the modified Apelblat model − can still achieve high accuracy in representing the solubility of solutes at multiple temperatures, which can be described in eq as follows: where T refers to the absolute temperature (K), x 1 is the mole fraction solubility of the solute at T ; A 0 , B 0 , and C 0 are model parameters.…”

“…Powder X-ray diffractometer (PANalytical B.V. X'Pert PRO MPD, Netherlands) analysis was performed to determine the existence of polymorph transition or solvate formation of N-benzyloxycarbonyl-L-tryptophan during the solubility measurement process in different solvents. 17,18 The sample preparation details are shown in the Supporting Information. PXRD was The mass fraction purity and the analysis methods were both provided by the suppliers.…”

“…d Gas chromatography. 17 the modified Apelblat model has become one of the most commonly and widely used models in solubility correlation and prediction, especially in engineering applications. Although expressed by a simple mathematical equation, the modified Apelblat model 19−22 can still achieve high accuracy in representing the solubility of solutes at multiple temperatures, which can be described in eq 2 as follows:…”