2023
DOI: 10.30827/ars.v64i4.27728
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Solubility data and solubility parameters of barnidipine in different pure solvents

Mª Ángeles Peña-Fernández,
Gaia Spanò,
Norma Sofía Torres Pabón
et al.

Abstract: Introduction: Solubility studies and obtaining physicochemical data on drugs in pure solvents belonging to different chemical classes are key to developing new drug formulations. In this work, Hansen partial solubility parameters (HSP) were calculated to assess the miscibility and intermolecular interactions of barnidipine in seventeen pure solvents. The comparison of the results obtained with the theoretical values ​​calculated according to the structure of barnidipine, were valuable to analyse the influence … Show more

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Cited by 3 publications
(1 citation statement)
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“…Both the polarity and hydrogen bonding parameters share a strictly molecular nature, while the dispersion parameter relies on induced dipole interactions with other molecules . HSPs have been previously explored as a promising method for predicting the solubility of many components including FDCA, cellulose, and other ring-containing organic compounds and pharmaceuticals with an overall focus on “like dissolves like.” ,, …”
Section: Theorymentioning
confidence: 99%
“…Both the polarity and hydrogen bonding parameters share a strictly molecular nature, while the dispersion parameter relies on induced dipole interactions with other molecules . HSPs have been previously explored as a promising method for predicting the solubility of many components including FDCA, cellulose, and other ring-containing organic compounds and pharmaceuticals with an overall focus on “like dissolves like.” ,, …”
Section: Theorymentioning
confidence: 99%