Solubility Data of Diazepam in Binary and Ternary Mixtures of PEGs 200 and 400 with N-Methyl Pyrrolidone and Water at 298.2 K: Experimental Data and Modeling

Soltanpour, Shahla; Panahi‐Azar, Vahid; Taheri, Azade; Bastami, Zahra; Jouyban, Abolghasem

doi:10.1007/s10953-013-0106-7

Cited by 10 publications

(3 citation statements)

References 25 publications

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“…14,15 In addition to experimental efforts to determine the solubility in monosolvents and binary solvent mixtures, a number of cosolvency models were proposed to calculate the solubility values. 16,17 Among the developed cosolvency models, the Jouyban−Acree model is the most simple, accurate, and versatile model and provides reasonable predictions of drug solubilities not only in aqueous mixtures of N,N-dimethylformamide (DMF), 18 N-methyl-2-pyrrolidone, 19 1,4-dioxane, 20,21 ethanol (EtOH), 22,23 ethylene glycols, 24 propylene glycol, 25 polyethylene glycol 200, 26 and polyethylene glycol 400 27 but also in multiple ternary solvent systems such as water− ethanol−propylene glycol, 28,29 water−propylene glycol−polyethylene glycol 400 or 600, 30 water−N-methylpyrrolidone− polyethylene glycol 200 or 400, 31 and water−ethanol−polyethylene glycol 600 32 at various temperatures. These findings were also supported for the solubility of drugs in a given water−cosolvent mixture after training the model using a minimum number of experimental data points.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Solubility determination of drugs in water–cosolvent mixtures provides useful data for better understanding of the solubility phenomenon in these media. Apart from experimentation works, the mathematical representation of solubility phenomenon is of value in prediction and accurate description of data and is of importance in different pharmaceutical fields including the preformulation stage of a new drug as well as formulation of the liquid dosage forms. , In addition to experimental efforts to determine the solubility in monosolvents and binary solvent mixtures, a number of cosolvency models were proposed to calculate the solubility values. , Among the developed cosolvency models, the Jouyban–Acree model is the most simple, accurate, and versatile model and provides reasonable predictions of drug solubilities not only in aqueous mixtures of N , N -dimethylformamide (DMF), N -methyl-2-pyrrolidone, 1,4-dioxane, , ethanol (EtOH), , ethylene glycols, propylene glycol, polyethylene glycol 200, and polyethylene glycol 400 but also in multiple ternary solvent systems such as water–ethanol–propylene glycol, , water–propylene glycol–polyethylene glycol 400 or 600, water– N -methylpyrrolidone–polyethylene glycol 200 or 400, and water–ethanol–polyethylene glycol 600 at various temperatures. These findings were also supported for the solubility of drugs in a given water–cosolvent mixture after training the model using a minimum number of experimental data points.…”

Section: Introductionmentioning

confidence: 99%

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Solubility of Etoricoxib in Aqueous Solutions of 1,4-Butanediol, 1,4-Dioxane, N,N-Dimethylacetamide, N,N-Dimethylformamide, Dimethyl Sulfoxide, and Ethanol at 298.2 K

Rathi¹,

Jouyban

Khoubnasabjafari

et al. 2015

J. Chem. Eng. Data

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Models for predicting the solubility of drugs in monosolvents and their mixtures have a practical importance in design and development of new products in pharmaceutical industries. Thus, present investigation pertains to the utility of a correlative model for solubility prediction of etoricoxib (ETR). The molar solubilities of ETR in a number of monosolvents and various mass fractions of their binary aqueous solvent mixtures were determined using the shake-flask method at 298.2 K. Densities of ETR saturated solutions in the monosolvents and their binary solvent mixtures were measured and then correlated using a well-established method proposed by Jouyban and Acree. Overall mean percentage deviations (OMPDs) between experimental and predicted values were 3.4 % for the molar solubilities and 0.1 % for the densities of the saturated solutions.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solubility of Etoricoxib in Aqueous Solutions of 1,4-Butanediol, 1,4-Dioxane, N,N-Dimethylacetamide, N,N-Dimethylformamide, Dimethyl Sulfoxide, and Ethanol at 298.2 K

Rathi¹,

Jouyban

Khoubnasabjafari

et al. 2015

J. Chem. Eng. Data

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“…water mixtures at 298.2 K [29]. The solubilities of these drugs were also investigated in some ternary solvent mixtures by our group [30][31][32][33]. To extend our systematic investigations on the solubility of drugs in mixed solvents, the apparent solubilities of CZP, DZP and LTG in ethanol ?…”

Section: Introductionmentioning

confidence: 99%

Solubilization of Clonazepam, Diazepam and Lamotrigine Using Ethanol and Sodium Dodecyl Sulfate

et al. 2014

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The apparent solubilities of clonazepam, diazepam and lamotrigine in binary mixtures of ethanol ? water at 298.2 K in the presence of three different concentrations of sodium dodecyl sulfate (SDS) are reported. Using this approach, 2250, 7733, and 153 times enhancement in the aqueous solubility of clonazepam, diazepam, and lamotrigine were achieved, respectively. Melting point and polar surface area were determined as indicators of solubility enhancement by SDS and ethanol, respectively. The Jouyban-Acree model was used for correlating the reported data and the obtained mean relative deviations are 7.2, 10.0 and 7.9 %, respectively. When all data points of clonazepam, diazepam and lamotrigine in binary solvents at various SDS concentrations were fitted to the model, the mean relative deviations are 10.0, 17.3, and 11.8 %, respectively. The results reveal that the model could be used for mathematical representation of cosolvent and surfactant concentrations on the solubility of these pharmaceuticals. This study shows that for aqueous solutions SDS is a solubility enhancer in the presence of organic solvents and this could be helpful in reducing the need for organic solvents in pharmaceutical dosage forms where avoidance of higher concentrations of organic solvents is desirable.

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Solubility of Ketoconazole in Binary and Ternary Solvents of Polyethylene Glycols 200, 400 or 600 with Ethanol and Water at 298.2 K. Data Report and Analysis

Soltanpour

Nazemi

2018

J Solution Chem

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Solubility Data of Diazepam in Binary and Ternary Mixtures of PEGs 200 and 400 with N-Methyl Pyrrolidone and Water at 298.2 K: Experimental Data and Modeling

Cited by 10 publications

References 25 publications

Solubility of Etoricoxib in Aqueous Solutions of 1,4-Butanediol, 1,4-Dioxane, N,N-Dimethylacetamide, N,N-Dimethylformamide, Dimethyl Sulfoxide, and Ethanol at 298.2 K

Solubility of Etoricoxib in Aqueous Solutions of 1,4-Butanediol, 1,4-Dioxane, N,N-Dimethylacetamide, N,N-Dimethylformamide, Dimethyl Sulfoxide, and Ethanol at 298.2 K

Solubilization of Clonazepam, Diazepam and Lamotrigine Using Ethanol and Sodium Dodecyl Sulfate

Solubility of Ketoconazole in Binary and Ternary Solvents of Polyethylene Glycols 200, 400 or 600 with Ethanol and Water at 298.2 K. Data Report and Analysis

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