Solubility Determination and Modeling for Artesunate in Binary Solvent Mixtures of Methanol, Ethanol, Isopropanol, and Propylene Glycol + Water

Abstract

Artesunate is dissolved in an aqueous solution of several organic solvents (methanol, ethanol, isopropanol, and PG), and the mole fraction of artesunate is determined by the static method. When the system reaches equilibrium, the range of system temperature is 278.15−318.15 K and the pressure environment is 101.1 kPa. When the temperature is constant, the equilibrium mole fraction of artesunate is proportional to the mass percentage of organic solvents, and the relationship between artesunate solubility and temperature is the same as before under certain conditions of the organic solvent component. When the external conditions are the same, artesunate is more likely to dissolve in the ethanol + water mixture than in several other systems. Besides, three classical mixed solvent thermodynamic equationsJouyban−Acree model, van't Hoff−Jouyban−Acree model, and Apelblat−Jouyban−Acree modelare applied to calculate the equilibrium mole fraction of artesunate. The maximum value of average relative deviations (ARD) obtained during the calculation is 0.83%. The experimentally measured data on artesunate has different general meanings for the expansion of application and production in the pharmaceutical field and provides theoretical data for its industrial production.

Determination and Data Correlation of Solubility of Sofosbuvir Polymorphs in Ethyl Acetate + Toluene and Methyl tert-Butyl Ether Binary Solvents at the Temperature Range from 268.15 to 308.15 K

“…The solubility of the sofosbuvir polymorphs, described in mole fraction x in different systems, was calculated by the following equation [18]: (8) in which m and m s represent the mass of sofosbuvir and the solvent, respectively; M and M s are the molecular mass of sofosbuvir and the solvent, respectively.…”

“…All of the masses were measured using an analytical balance (Mettler Toledo XS105, Switzerland) with an accuracy of ±0.01 mg. The solubility of the sofosbuvir polymorphs, described in mole fraction x in different systems, was calculated by the following equation [18]:…”

“…The solubility of the sofosbuvir polymorphs, described in mole fraction x in different systems, was calculated by the following equation [18]:…”

Measurement and Correlation of the Solubility of Aspirin in Four Binary Solvent Mixtures from T = 283.15 to 323.15 K

“…However, it is still difficult to predict the solubility of drugs directly. Classical solubility models are also based on experimentally measured solubility data . The solubility of aspirin has been reported only in some pure solvents. , However, solubility data in mixed solvents is more significant for the screening of crystals and spherulites.…”

Thermodynamic Modeling and Solubility Measurement of Cetirizine Hydrochloride and Deferiprone in Pure Solvents of Acetonitrile, Ethanol, Acetic Acid, Sulfolane, and Ethyl Acetate and Their Mixtures

“…Therefore, it is necessary to select an appropriate and safe solvent . For the reasons mentioned, solubility of different types of drug compounds has been investigated in aqueous and organic systems and presented in the literature. − …”