Solubility Determination, Correlation, and Solute–Solvent Molecular Interactions of 5-Aminotetrazole in Various Pure Solvents

The solubility of moroxydine hydrochloride was determined by the gravimetrical method (temperature from 283.15 to 323.15 K, pressure at 101.325 kPa) in 12 pure solvents (water, methanol, ethanol, 1-propanol, 1-butanol, 2-methyl-1propanol, 2-propanol, 1-pentanol, 2-butanol, acetonitrile, ethyl acetate, and acetone) and a binary system (water + 2-propanol). The results of this experiment suggested that the solubility data of moroxydine hydrochloride increased with increasing mole fraction of water and experimental temperature in all investigated neat and mixed solvent systems. The moroxydine hydrochloride solubility order in the 12 neat solvents was shown as water > methanol > ethanol > 1-propanol > 1-butanol > 2-methyl-1propanol > 2-propanol > 1-pentanol > 2-butanol > acetonitrile ≈ ethyl acetate ≈ acetone. For polar protic solvents except for 1-pentanol, the main factor influencing the solubility behavior was the polarity. While it was affected by complicating factors in polar aprotic solvents. The fitting results of the moroxydine hydrochloride solubility data obtained by the modified Apelblat, Jouyban−Acree, and Apelblat−Jouyban−Acree models were all satisfactory.

Section: Resultsmentioning

confidence: 93%

Measurement and Correlation for Solubility of Moroxydine Hydrochloride in Pure and Binary Solvents

Qiu

et al. 2020

“…In addition, although the solubility of l -alanine in polar protic solvents was higher than that in polar aprotic solvents, the order in the two kinds of solvents was both inconsistent with the polarity, dipole moment, dielectric constant, and solubility parameter orders (the solvent properties can be seen in Table ). This indicated that the dissolution equilibrium of l -alanine was a complex phenomenon, which may be attributed to the comprehensive influence of various factors, such as solvent properties, molecular sizes and shapes, solute–solvent interactions, solvent–solvent interactions, solute–solute interactions, steric effect, etc. − From Figure b, there were some intersects between the solubility curves, which may result from the weight differences of the above factors under different temperatures. , …”

Section: Resultsmentioning

confidence: 95%

Measurement and Correlation for Solubility of l-Alanine in Pure and Binary Solvents at Temperatures from 283.15 to 323.15 K

An¹,

Qiu²,

Yi³

et al. 2020

The solubility of l-alanine in five binary systems water + methanol, water + ethanol, water + 1-propanol, water + 2-propanol, and water + acetone and 12 neat solvents (water, 1-butanol, methanol, 2-butanol, 2-methyl-1-propanol, 1-pentanol, 1-propanol, ethanol, 2-propanol, ethyl acetate, acetonitrile, and acetone) was determined by the gravimetrical method within the temperature range from 283.15 to 323.15 K under atmospheric pressure. The experimental results indicated that the solubility increased with increasing temperature and mole ratio of water in all investigated solvents and decreased with the rise of the mole fraction of five different organic solvents in the binary solvent systems. The order of l-alanine solubility in the selected pure solvents was water > 1-butanol > methanol ≈ 2-butanol > 2-methyl-1-propanol ≈ 1-pentanol ≈ 1-propanol ≈ ethanol > 2-propanol > ethyl acetate > acetonitrile > acetone. The solubility was mathematically represented by the modified Apelblat, Jouyban–Acree, and Apelblat–Jouyban–Acree models. All the models can be found to agree well with the data in the experiment.

“…The solubility of edaravone in (ethyl acetate + n -propanol), (acetonitrile + methanol), (acetonitrile + ethanol), and (acetonitrile + n -propanol) was determined by the isothermal saturation method. − Four mixtures were prepared by using an analytic balance with the standard uncertainty of 0.0001 g. The mass fractions of ethyl acetate or acetonitrile in the mixtures varied from 0.2 to 0.8. The experimental process is the same as our previous studies, − so it is only a simple description of the experimental steps.…”

Section: Methodsmentioning

confidence: 99%

Solubility of Edaravone in Four Mixed Solvents at 273.15–313.15 K and Correlation of Jouyban–Acree and CNIBS/R–K Models

Yin

Tang

et al. 2020

Self Cite

The solubility of edaravone in four mixed solvents including (ethyl acetate + n-propanol), (acetonitrile + methanol), (acetonitrile + ethanol), and (acetonitrile + n-propanol) was determined by using the isothermal saturation method at temperatures ranging from (273.15 to 313.15) K under 101.3 kPa. At a certain composition in the four mixed solvents, the solubility data of edaravone increased with the rising temperature. At a certain temperature, the solubility data decreased monotonically with the increasing mass fraction of acetonitrile in the mixture of (acetonitrile + n-propanol). Whereas in (ethyl acetate + n-propanol), (acetonitrile + methanol), and (acetonitrile + ethanol), it increased first and then decreased with the increasing mass fraction of ethyl acetate or acetonitrile. The composition dependence of solubility has a maximum at around w ethyl acetate = 0.2 in (ethyl acetate + n-propanol) or w acetonitrile = 0.2 in (acetonitrile + ethanol) and w acetonitrile = 0.4 for mixtures of (acetonitrile + methanol). The results obtained in the selected four mixtures were correlated by the Jouyban–Acree model and CNIBS/R–K model. The largest relative average deviation and root-mean-square deviation values were found in (acetonitrile + methanol) calculated by the Jouyban–Acree model and were no more than 4.71 × 10–2 and 22.32 × 10–4, respectively. Statistical analysis of experimental and calculated values shows that the residual of CNIBS/R–K model is smaller, and the linear correlation coefficient is closer to 1. Therefore, the CNIBS/R–K model is more suitable to correlate the solubility values of edaravone in the four mixed solvents including (ethyl acetate + n-propanol), (acetonitrile + methanol), (acetonitrile + ethanol), and (acetonitrile + n-propanol). The experimental data and model parameters obtained will play an important role in the preparation and purification of edaravone.