Solubility determination, dissolution properties and solid transformation of resmetirom (form A) in heptane and seven alcohols

Abstract

The solubility of resmetirom (form A) was first systematically acquired in some solvents from 273.15 K to 333.15 K. And a high-precision quantification method was established to study the transformation process between form A and solvates.

Structure Determination and 3D ED/MicroED-Guided Synthesis of a New (S)-Ibuprofen–l-phenylalanine Co-Crystal

“…Active pharmaceutical ingredients (APIs) exist in a variety of solid forms . Drug cocrystal is the application of supramolecular chemistry in the pharmaceutical industry.…”

“…Active pharmaceutical ingredients (APIs) exist in a variety of solid forms. 1 Drug cocrystal is the application of supramolecular chemistry in the pharmaceutical industry. It is composed of drug-active components and cocrystal coformers (CCFs) through nonionic and noncovalent bonds (including hydrogen bonding, halogen bonding, π−π multicomponent crystal formed by stacking effect, etc.).…”

Development and Validation of a Raman Spectroscopy Concentration Calibration Model to Enhance Crystallization Kinetic Model-Based Control: A Case Study of dl-methionine

“…10,11 In addition, by comparing the experimental IR spectroscopy and simulated IR spectroscopy, a new high-precision quantitative method has been developed to study the solidstate transformation process. 12,13 Zhou et al used Fourier transform infrared (FTIR) spectroscopy to conduct online concentration monitoring and supersaturation control of the antisolvent crystallization process of paracetamol. 8 Mark et al utilized in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to monitor the concentration of benzoic acid in solution to control the degree of supersaturation, which improved product growth and particle size.…”

“…In recent years, a multitude of PAT tools have been developed for application in the regulation of crystallization operating parameters . Spectroscopy, such as infrared (IR) spectroscopy and Raman spectroscopy, has been widely applied to monitor solute concentration changes in crystallization processes. − Lu et al used solid-phase characterization by infrared spectroscopy to distinguish chiral amino acid crystals with different rotational properties. , In addition, by comparing the experimental IR spectroscopy and simulated IR spectroscopy, a new high-precision quantitative method has been developed to study the solid-state transformation process. , Zhou et al used Fourier transform infrared (FTIR) spectroscopy to conduct online concentration monitoring and supersaturation control of the antisolvent crystallization process of paracetamol . Mark et al utilized in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to monitor the concentration of benzoic acid in solution to control the degree of supersaturation, which improved product growth and particle size .…”