Solubility enhancement and drug release mechanism of polymeric micelles

Kenguva, Gowtham; Rout, Smruti Rekha; Fatima, Mahak; Dubey, Sunil Kumar; Alexander, Amit; Abourehab, Mohammed A.S.; Kesharwani, Prashant; Dandela, Rambabu

doi:10.1016/b978-0-323-89868-3.00006-9

Cited by 10 publications

(2 citation statements)

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“…Nevertheless, TRD's therapeutic use is severely limited due to its high hydrophobicity, narrow safety margin, significant systemic toxic side effects (including liver and liver damage), along with short duration of effectiveness. [118] Inflammation within the joints creates a weakly acidic microenvironment, with a pH around 6.0. This occurs because inflamed tissues have a highly metabolic environment and limited blood supply, leading to high anaerobic glycolysis and excessive production of lactate.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

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Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

Fatima,

Almalki,

Khan

et al. 2024

Advanced Materials

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The quest for effective and reliable methods of delivering medications, with the aim of improving delivery of therapeutic agent to the intended location has presented a demanding yet captivating field in biomedical research. The concept of smart drug delivery systems is an evolving therapeutic approach, serving as a model for directing drugs to specific targets or sites. These systems have been developed to specifically target and regulate the administration of therapeutic substances in a diverse array of chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel diseases, rheumatoid arthritis, and different cancers. Nevertheless, numerous comprehensive clinical trials are still required to ascertain both the immediate and enduring impacts of such nanosystems on human subjects. This review delves into the benefits of different drug delivery vehicles, aiming to enhance comprehension of their applicability in addressing present medical requirements. Additionally, it touches upon the current applications of these stimuli‐reactive nanosystems in biomedicine and outlines future development prospects.This article is protected by copyright. All rights reserved

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Section: Rheumatoid Arthritismentioning

confidence: 99%

Section: Stimuli‐responsive Nanoparticles For Combating Different Dis...mentioning

confidence: 99%