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Apigenin is a flavonoid belonging to a flavone subclass that is reported to have many benefits and less toxic than other flavonoid groups. Objective: The purpose of this study is to evaluate antinephrolithiasis activity of modified Hot Melt Extrusion (HME) apigenin formulas with Soluplus® and Kollidon® VA 64 polymers in rats. Method: In this study, rats were administered ethylene glycol 0.75% and ammonium chloride 2% as inducing agents for formation of kidney stone. Rats in each group were given the formulas of apigenin without HME, or apigenin with HME soluplus® polymer and apigenin with HME Kollidon® VA 64 polymer every day for seven days. The concentration of calcium oxalate in the kidney and the urine was measured using the atomic absorption spectrophotometer (AAS). Urine volume and urine pH were also measured. Result: The results of this study indicated that the apigenin formulas with HME soluplus® polymers can shed kidney stones at a dose of 4.8mg/kg of body weight. Its effect was stronger than the apigenin formula with Kollidon®. Conclusion: The formula of Apigenin with HME Soluplus® polymers is better than that of Kollidon® polymers in removing kidney stones with the ratio of 10:90 at a dose of 4.8mg/kg.
Apigenin is a flavonoid belonging to a flavone subclass that is reported to have many benefits and less toxic than other flavonoid groups. Objective: The purpose of this study is to evaluate antinephrolithiasis activity of modified Hot Melt Extrusion (HME) apigenin formulas with Soluplus® and Kollidon® VA 64 polymers in rats. Method: In this study, rats were administered ethylene glycol 0.75% and ammonium chloride 2% as inducing agents for formation of kidney stone. Rats in each group were given the formulas of apigenin without HME, or apigenin with HME soluplus® polymer and apigenin with HME Kollidon® VA 64 polymer every day for seven days. The concentration of calcium oxalate in the kidney and the urine was measured using the atomic absorption spectrophotometer (AAS). Urine volume and urine pH were also measured. Result: The results of this study indicated that the apigenin formulas with HME soluplus® polymers can shed kidney stones at a dose of 4.8mg/kg of body weight. Its effect was stronger than the apigenin formula with Kollidon®. Conclusion: The formula of Apigenin with HME Soluplus® polymers is better than that of Kollidon® polymers in removing kidney stones with the ratio of 10:90 at a dose of 4.8mg/kg.
Dissolvability assumes an essential part in accomplishing the imperative grouping of prescription in the circulation system to exhibit pharmacological impacts, as it includes the course of a strong substance dissolving in a fluid stage to make a uniform combination. The essential test experienced in forming drugs is the restricted watery solvency of novel medication particles. At the point when inadequately dissolvable medications are managed orally, higher portions are expected to achieve the ideal helpful plasma fixation. Administrative bodies and wellbeing associations use the Bio drug Order Framework to classify intensifies in light of their dissolvability and penetrability. This order framework is utilized to lay out bio equality for substances that are exceptionally dissolvable and profoundly penetrable, involving disintegration for the purpose of evidence. Drugs displaying poor watery solvency experience slow disintegration rates, bringing about commonly low bio accessibility upon oral organization. This survey article expects to investigate methodologies for accomplishing successful ingestion and improving bio accessibility. This article examines different procedures and techniques for working on the dissolvability of inadequately solvent medications. Solvency is essential for a medication's successful fixation at the objective activity site. The decision of strategy relies upon the medication's temperament, properties, and pharmacokinetic conduct. Different strategies can be utilized separately or in mix to further develop drug dissolvability. The decision of strategy relies upon the medication's quality, viability, and relationship with different synthetic compounds, dependability, and final result yield, while likewise thinking about financial variables.
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