Solubility enhancement of miconazole nitrate: binary and ternary mixture approach

Kumar, Vineet; Dwivedi, Harinath; Yadav, Narayan Prasad; Chanotiya, Chandan Singh; Saraf, Shubhini A.

doi:10.3109/03639045.2013.801487

Cited by 19 publications

(7 citation statements)

References 27 publications

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“…5). These observations were consistent with previous reports, showing that the improved wettability resulted from the presence of hydrophilic groups like hydroxyl groups in hydrophilic polymers has a beneficial effect, possibly by a molecular interaction of drug and polymers or the ability to form hydrogen bonds with water and increase drug water solubility [22,23]. Comparing the dissolution profiles of binary (B4) and ternary (T6) SD's, the ternary SD exhibited the highest DE 30 % (~ 70%) (Table 2).…”

Section: Dissolution Studysupporting

confidence: 93%

“…The aqueous solubility of TMC elevated from 0.92 mM in the absence of PEG 6000 to1.61 mM in the presence of 12.5 mM PEG 6000 ~ a one and half fold increase in drug solubility. Enhancement of TMC solubility in case of PEG was mainly attributed to increased drug wettability due to the higher level of hydrophilicity of this polymeric carrier [22,23].…”

Section: Construction Of Tmc-peg 6000 Phase Solubility Diagrams In Pr...mentioning

confidence: 99%

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Comparative Studies on Dissolution and Bioavailability of Tamoxifen Citrate Loaded Binary and Ternary Solid Dispersions

Shaker

2014

BJPR

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Section: Dissolution Studysupporting

confidence: 93%

Section: Construction Of Tmc-peg 6000 Phase Solubility Diagrams In Pr...mentioning

confidence: 99%

Comparative Studies on Dissolution and Bioavailability of Tamoxifen Citrate Loaded Binary and Ternary Solid Dispersions

Shaker

2014

BJPR

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“…In MCZ spectra ( Figure 8 ), absorption peak characteristics of C-H stretching were observed between 3182–3107 cm −1 , which can be attributed to the aromatic rings or the imidazole. Pairwise absorptions at 1586 and 1545 cm −1 refer to aromatic and imidazole C=C stretching, while the peaks at 1330 cm −1 and 1082 cm −1 represent C=N and C-O stretching vibrations, respectively [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

The Efficacy of Hybrid Vaginal Ovules for Co-Delivery of Curcumin and Miconazole against Candida albicans

Bezerra,

y Araújo,

Alves-Júnior

et al. 2024

Pharmaceutics

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Curcumin (CUR) is a natural compound that can be combined with miconazole (MCZ) to improve vulvovaginal candidiasis (VVC) caused by Candida albicans treatment’s efficacy. This study aimed to develop ureasil–polyether (U-PEO) vaginal ovules loaded with CUR and MCZ for the treatment of VVC. Physicochemical characterization was performed by thermogravimetry (TGA), differential thermal analysis (DTA), Fourier transform infrared spectroscopy (FTIR), and in vitro release. Antifungal assays were used to determine minimum inhibitory concentrations (MICs) and synergism between CUR and MCZ, and the activity of U-PEO ovules were performed by microdilution and agar diffusion. TGA results showed high thermal stability of the hybrid ovules. In DTA, the amorphous character of U-PEO and a possible interaction between CUR and MCZ were observed. FTIR showed no chemical incompatibility between the drugs. In vitro release resulted in 80% of CUR and 95% of MCZ released within 144 h. The MICs of CUR and MCZ were 256 and 2.5 µg/mL, respectively. After combining the drugs, the MIC of MCZ decreased four-fold to 0.625 µg/mL, while that of CUR decreased eight-fold to 32 µg/mL. Synergism was confirmed by the fractional inhibitory concentration index (FICI) equal to 0.375. U-PEO alone showed no antifungal activity. U-PEO/MCZ and U-PEO/CUR/MCZ ovules showed the greatest zones of inhibition (≥18 mm). The results highlight the potential of the ovules to be administered at a lower frequency and at reduced doses compared to available formulations.

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“…Solubility enhancement strategies increase the solubility of poorly watersoluble drugs and provide opportunities to establish their mucoadhesive form of semi-solid dosage. 66,67 Factors to be considered during the production of buccal mucosa formulations are the release and penetration of drugs through buccal mucosa. In addition to physicochemical properties, the organoleptic properties of the drug or the delivery system should also be considered.…”

Section: Pharmaceutical Aspectsmentioning

confidence: 99%

A Review on Bucco-Adhesive Drug Delivery Systems for Oral Sub-Mucous Fibrosis: Challenges, Opportunities and Future Perspectives

Bhardwaj¹,

Tripathi²,

Mallikarjuna³

et al. 2020

Int Res J Pharm

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Oral sub-mucous fibrosis (OSF) is a chronic, insidious disease which might affect the oral cavity (oral mucosa) including pharynx and larynx. Numerous approaches and anticancer molecules have been explored in the literature to treat OSF with different modes of action. However, complete cure for OSF is limited due to the lack of an ideal carrier for safe and effective delivery of potent drug moieties. There are several challenges such as anatomical or histological barriers and appropriate animal model need to be explored and optimized to develop the efficient treatment for oral sub-mucous fibrosis. Constant progression in the development of new formulations has led to the effective management of the disease associated with the mucosa using mucosal or muco-adhesive drug delivery systems. Muco-adhesive drug delivery systems (such as gel and patches) have gained unique position as drug cargoes. Therefore, present review is an attempt to contemplate on OSF in terms of pathogenesis, currently available treatment shaving their mode of action, major challenges encountered during treatment, usefulness/feasibility of muco-adhesive dosage forms, opportunities/future scope of muco-adhesive drug delivery in OSF and recent developments in the delivery of various anti-cancer drugs in the treatment of OSF.

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Solubility enhancement of miconazole nitrate: binary and ternary mixture approach

Abstract: Owing to the excellent solubility enhancement potential of ternary mixtures in enhancing MN solubility from 110.4 μg/ml to 57640.0 μg/ml, ternary mixture approach could prove to be promising in the development of oral/mucoadhesive formulations.

Cited by 19 publications

References 27 publications

Comparative Studies on Dissolution and Bioavailability of Tamoxifen Citrate Loaded Binary and Ternary Solid Dispersions

Comparative Studies on Dissolution and Bioavailability of Tamoxifen Citrate Loaded Binary and Ternary Solid Dispersions

The Efficacy of Hybrid Vaginal Ovules for Co-Delivery of Curcumin and Miconazole against Candida albicans

A Review on Bucco-Adhesive Drug Delivery Systems for Oral Sub-Mucous Fibrosis: Challenges, Opportunities and Future Perspectives

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