Solubility Enhancement of Modafinil by Complexation with &amp;#946;-cyclodextrin and Hydroxypropyl &amp;#946;-cyclodextrin: A Response Surface Modeling Approach

Mahapatra, Anjan Kumar; Murthy, Padala Narasimha; Patra, Ruchita Kumari; Pattnaik, Satyanarayan

doi:10.2174/22103031113039990005

Cited by 11 publications

(6 citation statements)

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“…The notable drawback of the hydrophobic drug in clinical practice is the poor solubility and low bioavailability after conventional administration (Mahapatra et al, 2013). Mesoporous materials are promising carriers for poorly soluble drugs.…”

Section: Mesoporous Carbon Nanomaterialsmentioning

confidence: 99%

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath

Srivastava

2021

Front. Nanotechnol.

137

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With growing interest, a large number of researches have been conducted on carbon-based nanomaterials (CBNs). However, their uses are limited due to comprehensive potential environmental and human health effects. It is often confusing for researchers to make an informed choice regarding the versatile carbon-based nanocarrier system and its potential applications. This review has highlighted emerging applications and cutting-edge progress of CBNs in drug delivery. Some critical factors like enzymatic degradation, surface modification, biological interactions, and bio-corona have been discussed here. These factors will help to fabricate CBNs for effective drug delivery. This review also addresses recent advancements in carbon-based target specific and release controlled drug delivery to improve disease treatment. The scientific community has turned their research efforts into the development of novel production methods of CBNs to make their production more attractive to the industrial sector. Due to the nanosize and diversified physical properties, these CBNs have demonstrated distinct biological interaction. Thus long-term preclinical toxicity study is recommended before finally translating to clinical application.

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Section: Mesoporous Carbon Nanomaterialsmentioning

confidence: 99%

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath

Srivastava

2021

Front. Nanotechnol.

137

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“…Based primarily on the physicochemical properties of the active ingredients, a diverse strategy for active ingredient delivery has been proposed to increase the solubility and/or the rate of dissolution of such molecules. 6 These fascinating techniques include chemical modification, 7 cocrystals, 8 micro-/ nanonization, 3,5,6 polymorphic improvements, 9 lipid-based systems, 6,10 micellar solubilization in-cluding self-emulsifying drug delivery systems, 11 inclusion complexes, [12][13][14][15] amorphous solid dispersion/solution [16][17][18] etc. In addition, nanotechnology has provided solutions for improving the solubility and/or bioavailability of active ingredients.…”

Section: Introductionmentioning

confidence: 99%

Ibuprofen Loaded Electrospun Polymeric Nanofibers: A Strategy to Improve Oral Absorption

Panda

Alruwaili

Pattnaik³

et al. 2022

ACSi

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The poor aqueous solubility of candidate drugs has presented a great challenge to formulation scientists for their effective oral delivery. Poor solubility is often associated with poor dissolution behavior and, subsequently, poor bioavailability for those drugs when intestinal absorption is dissolution rate limited. In the present study electrospun polymeric nanofibers were developed to address the poor aqueous solubility of ibuprofen, a Biopharmaceutic Classification System (BCS) class-II drug. Hydrophilic spinnable polymers like polyvinyl pyrrolidone were deployed as a carrier system for the fabrication of nanofibers. The electrospinning parameters like flow rate, voltage, and spinneret to collector distance were optimized. The fabricated ibuprofen-loaded nanofibers were characterized using scanning electron microscopy and differential scanning calorimetry. Drug release studies and ex vivo intestinal absorption studies were also carried out. The nanofiber-based platform significantly improved in vitro absorption of ibuprofen compared to pure ibuprofen crystals.

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“…The interaction between the host and guest molecules is solely van der Waals bonding. Inclusion complexation has been widely exploited by researchers worldwide for the improvement of drug solubility and subsequent improvement of drug bioavailability (Mahapatra et al, 2013; Mallick et al, 2007; Roy et al, 2020). The cyclodextrins are the wonderful host molecules often used in drug delivery science for the formation of inclusion complexes.…”

Section: Nanofiber For Delivery Of Poorly Soluble Drugsmentioning

confidence: 99%

“…Diverse drug delivery strategies have been suggested to improve the solubilization and/or the dissolution velocity of such molecules (Mallick et al, 2007; Mallick et al, 2008; Pattnaik & Pathak, 2017; Pattnaik, Swain, Rao, Talla, et al, 2015). These intriguing techniques encompass chemical modification (Mallick et al, 2007; Takahashi et al, 2020), co‐crystals (Nechipadappu et al, 2017; Teoh et al, 2020), micro/nanonization (Pattnaik, Swain, Manaswini, Divyavani, et al, 2015; Pattnaik, Swain, Rao, Varun, & Subudhi, 2015), polymorphic ameliorations (Liu et al, 2015), lipid‐based systems (Castro & Lindqvist, 2020; Rahman et al, 2019), micellar solubilization which includes self‐emulsifying drug delivery systems (Chou et al, 2020; Yang et al, 2019), inclusion complexes (Mahapatra et al, 2013), amorphous solid dispersion/solution (Guo et al, 2021; Smeets et al, 2018), etc. Nanotechnology has additionally contributed nicely to seeking solutions for improved solubility and/or bioavailability of drug substances (Panda et al, 2022; Pattnaik, Swain, Manaswini, Divyavani, et al, 2015; Pattnaik, Swain, Rao, Varun, & Subudhi, 2015).…”

Section: Introductionmentioning

confidence: 99%

Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions

Pattnaik

Swain

Ramakrishna

2022

WIREs Nanomed Nanobiotechnol

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Poor aqueous solubility of both, existing drug molecules and those which are currently in the developmental stage, have posed a great challenge to pharmaceutical scientists because they often exhibit poor dissolution behavior and subsequent poor and erratic bioavailability. This has triggered extensive research to explore nanotechnology‐based technology platforms for possible rescue. Recently, nanofibers have been exploited widely for diverse biomedical applications including for drug delivery. Electrospun nanofibers are capable of preserving the homogeneously loaded therapeutic agents in amorphous state potentialy impairing devitrification. The present review aims at providing an overview of the various key factors that affect the electrospinning process and characteristics of the nanofibers while fabrication of drug loaded nanofibers for poorly soluble drug candidates. The review explores various methodological advancements in the electrospinning process and set‐ups for production scale‐up. The various types of electrospun nanofibers (like simple matrix, core‐sheath, Janus, and inclusion complex nanofibers) that have been exploited for the delivery of poorly soluble drugs are also critically assessed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Solubility Enhancement of Modafinil by Complexation with β-cyclodextrin and Hydroxypropyl β-cyclodextrin: A Response Surface Modeling Approach

Cited by 11 publications

References 0 publications

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Ibuprofen Loaded Electrospun Polymeric Nanofibers: A Strategy to Improve Oral Absorption

Optimal delivery of poorly soluble drugs using electrospun nanofiber technology: Challenges, state of the art, and future directions

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