Solubility Enhancement of Some Water-Insoluble Drugs in the Presence of Nicotinamide and Related Compounds

Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution

“…Caffeine (CAF) and Nicotinamide (NMD) are well known as hydrotropic agents and their ability to solubilize a wide variety of therapeutic drugs including Riboflavine [Coffman and Kildsig, 1996a;Rasool et al, 1991;Lim and Go, 2000;Jain et al, 1996] has been demonstrated.…”

“…A number of mechanisms have been reported to account for the observed solubilizing effect of drugs by CAF and NMD in water, namely, a specific interaction with solvent [Coffman and Kildsig, 1996a], self-association of the hydrotrope [Coffman and Kildsig, 1996b] and complexation between the hydrotrope and drug; the latter mechanism has been the focus of many studies of drug complexation by CAF and NMD using different experimental methods [Rasool et al, 1991;Lim and Go, 2000;Jain et al, 1996;Hussain et al, 1993;Khalil, 1996] and molecular modeling studies [Fawzi et al, 1980;Datta et al, 2003]. …”

Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery

“…In addition, the polar groups may interact with drugs via hydrogen bonding (38). For example, nicotinamide, a typical hydrotrope, has been shown to form complexes with various hydrophobic drugs and enhance their water solubility (39). It has a pyridine ring that promotes the π-π stacking with drug molecules through its planarity (40).…”

Artesunate Loaded Self Nanoemulsified Drug Delivery System: A Preliminary Study for Improved Efficacy in the Treatment of Malaria: Formulation, Characterization and Bio-Distribution Study

“…For improving the bioavailability and solubility of such oral drug delivery system, it is required to formulate suitable formulations. The main challenge for the formulation scientist has been the formulation and development of poorly water soluble moieties [2][3][4][5]. The lipid based formulation methodology has seen wide range of interest in improving the oral bioavailability and the drug solubilisation in the Gastrointestinal Tract (GIT) of BCS class II and IV drugs [6][7][8][9].…”