Solubility: it's not just for physical chemists

Influence of the Solid Form of Siramesine Hydrochloride on its Behavior in Aqueous Environments

“…Above pH max the solid phase in equilibrium with the solution is the free base. Thus, if the pH max is lower than the pH of the intestine, precipitation of the free base may occur (15,19). Of the chosen pH values, pH 3.4 is almost six pH-units below the pK a of the drug.…”

Predicting the Solubility of the Anti-Cancer Agent Docetaxel in Small Molecule Excipients using Computational Methods

“…The physico-chemical characteristics of the drug-excipient blend are known to determine the properties and performance of the formulation (7,8). Specifically, the drug loading and retention properties of the formulation are largely influenced by the solubility of the drug in the excipient or miscibility of the drug-excipient blend as well as the presence of specific interactions between the drug and the excipient (9,10).…”

“…The ability of an excipient to solubilize DTX may be expressed in terms of the Hildebrand solubility parameter (d HIL ) which describes the behavior of apolar and non-interacting liquids (31). However, the presence of hydrogen-bonding interactions can also influence the solubility of compounds (10,32,33). Therefore, in order to more accurately describe the behavior of the mixtures with consideration given to the polar effects and hydrogen-bonding interactions, the Hansen solubility parameter (d HAN ) and Flory-Huggins interaction parameter (c FH ) were calculated (31).…”

Solubility of Pharmaceutical Solids

“…Compared with data in other frequently used media, solubility data in fasted simulated gastric fluid (FaSSGF) provide a better assessment of intragastric solubility during a bioavailability study in the fasted state. However, it is more difficult to simulate the fed state due to the complexity of the fed state in vitro (Bhattachar et al, 2006).…”