Solubility Measurement and Correlation for ε-2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane in Five Organic Solvents at Temperatures between 283.15 and 333.15 K and Different Chloralkane + Ethyl Acetate Binary Solvents at Temperatures between 283.15 and 323.15 K

Cui, Chao; Ren, Hui; Huang, Yangfei; Jiao, Qingze

doi:10.1021/acs.jced.6b00664

Cited by 22 publications

(14 citation statements)

References 23 publications

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“…The solubility of a substance in different solvent or solvent mixtures could be influenced by several factors, such as the Coulombic force, viscosity, dielectric constant, and polarization force. − The increase of solubility in the above binary solvent mixtures might be caused by a complex hydrogen-bond effect with the additive water . In the crystallization process, the MSZW (metastable zone width) might change with increasing solubility resulting from adding water, which was the key kinetic parameter, and would affect the nucleation , and growth , step of crystallization.…”

Section: Results and Discussionmentioning

confidence: 99%

Solubility Measurement and Modeling of Eszopiclone in Four Binary Solvents

Sun

Yao

et al. 2020

J. Chem. Eng. Data

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The solubility of eszopiclone in four binary solvents (ethanol + water, tetrahydrofuran + water, acetonitrile + water, acetone + water) at the temperature range of T = (288.15−328.15) K was determined with the gravimetric method. The experimental results showed that the solubility of eszopiclone increased as temperature rose. It was observed that the solubility varied in the binary solvent systems with the change in the fraction of water. The dissolution ability of the aqueous solvent mixtures was obviously improved with the added water. The characterization of the solid samples with X-ray powder diffraction showed that the crystal form of eszopiclone remained stable in this experiment. The increase of solubility in a binary solvent system may be related to the effect of a hydrogen bond. The experimental solubility data were correlated with the solvent composition and temperature using the CNIBS/R-K model and the Jouyban−Acree model. It was found that the calculated solubility was consistent with the experimental data. These results could give guidance to practical industrial processes such as the design of a crystallization process.

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Section: Results and Discussionmentioning

confidence: 99%

Solubility Measurement and Modeling of Eszopiclone in Four Binary Solvents

Sun

Yao

et al. 2020

J. Chem. Eng. Data

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“…Further, there are several factors to affect the solubility of azoxystrobin in the binary mixed solvents, such as viscosity, dielectric constant, and solubility parameter. − The detailed mechanism of this phenomenon can be studied deeply in the future work.…”

Section: Resultsmentioning

confidence: 99%

Measurement and Correlation of the Solubility of Azoxystrobin in Seven Monosolvents and Two Different Binary Mixed Solvents

Yang

Zhang

et al. 2017

J. Chem. Eng. Data

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A gravimetric method was used to determine the solubility of azoxystrobin in seven monosolvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, and ethyl acetate) and two binary mixed solvents (n-propanol + ethyl acetate and methanol + ethyl acetate) at different temperatures from 288.15 to 328.15 K. The solubility of azoxystrobin is positively related with temperature in all selected solvents. Moreover, the solubility of azoxystrobin in methanol + ethyl acetate binary mixed solvent reaches a maximum when the mole fraction of ethyl acetate is 0.8, differing from that in n-propanol + ethyl acetate binary mixed solvent. The Apelblat, λh, combined nearly ideal binary solvent/ Redlich−Kister, and nonrandom two-liquid model (NRTL) equations were applied to correlate the solubility of azoxystrobin, and all of the equations provided good fitting results to the data. In addition, the mixing thermodynamic properties of azoxystrobin in binary mixed solvents were calculated based on the NRTL equation. The results demonstrate that the mixing process in the experimental binary mixed solvents is endothermic and spontaneous.

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“…Interestingly, when the mole fraction of methanol declined to a certain value 0.8, the solubility decreases slightly with the increasing temperature. It may be caused by the intermolecular interactions and the steric hindrance between binary solvents and solvent. , …”

Section: Results and Discussionmentioning

confidence: 99%

Solubility Measurement and Correlation of Fosfomycin Sodium in Six Organic Solvents and Different Binary Solvents at Temperatures between 283.15 and 323.15 K

et al. 2017

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The solubility data of fosfomycin sodium (FOM-Na) in six pure solvents (methanol, ethanol, propanol, cyclohexane, acetone, N,N-dimethylformamide) and two binary solvents (methanol + ethanol, methanol + acetone) at temperatures ranging from 283.15 to 323.15 K were measured by a laser monitoring dynamic method at atmospheric pressure. It turned out that the solubility data decreased with increasing temperature, and also varies with the composition of the solvents. Moreover, the experimental data in pure solvents have been correlated with two thermodynamic models (i.e., modified Apelblat and van’t Hoff), and the data in binary solvents have been correlated with CNIBS/R-K equation and two modified versions of Jouyban–Acree models (Van’t-JA equation and Apel-JA equation), respectively. All the results showed a good agreement with the experimental data. Intermolecular interaction force and dielectric constants are introduced to explain the relationship between solubility and temperature. In addition, the analysis of the solubilities implies that higher temperature may destroy the forces between the solvent and solute molecules, leading to lower solubility. And this can give a guide to the design and optimization of the crystallization process of FOM-Na in the industry.

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Solubility Measurement and Correlation for ε-2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane in Five Organic Solvents at Temperatures between 283.15 and 333.15 K and Different Chloralkane + Ethyl Acetate Binary Solvents at Temperatures between 283.15 and 323.15 K

Cited by 22 publications

References 23 publications

Solubility Measurement and Modeling of Eszopiclone in Four Binary Solvents

Solubility Measurement and Modeling of Eszopiclone in Four Binary Solvents

Measurement and Correlation of the Solubility of Azoxystrobin in Seven Monosolvents and Two Different Binary Mixed Solvents

Solubility Measurement and Correlation of Fosfomycin Sodium in Six Organic Solvents and Different Binary Solvents at Temperatures between 283.15 and 323.15 K

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