2024
DOI: 10.1021/acs.jced.3c00587
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Solubility Measurement and Correlation of Alprazolam in Carbon Dioxide with/without Ethanol at Temperatures from 308 to 338 K and Pressures from 120 to 300 bar

Seyed Ali Sajadian,
Hamidreza Bagheri,
Pavel Gurikov
et al.

Abstract: This research investigated the solubility of alprazolam in supercritical carbon dioxide (scCO 2 ) with the addition of ethanol as a cosolvent. The solubility was examined at various pressures (ranging from 120 to 300 bar) and temperatures (ranging from 308 to 338 K). The solubility of alprazolam in scCO 2 ranged from 0.027 × 10 −4 to 0.632 × 10 −4 . When ethanol was used as a cosolvent, the solubility increased to a range of 0.157 × 10 −4 to 1.660 × 10 −4 (with 1 mol % ethanol) and 0.449 × 10 −4 to 3.167 × 10 … Show more

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Cited by 8 publications
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