Solubility Measurement and Data Correlation of Clopidogrel Hydrogen Sulfate (Form I) in Four Binary Solvents Systems at Temperature from 278.15 to 318.15 K

Abstract

Experimental solubility data of clopidogrel hydrogen sulfate (form I) in four binary solvents (1-propanol + isopropyl acetate, 2-propanol + isopropyl acetate, 1-butanol + isopropyl acetate, and 2-butanol + isopropyl acetate) was measured by using the laser dynamic method at the temperature ranging from 278.15 to 318.15 K. The experimental results showed that the solubility of clopidogrel hydrogen sulfate (form I) increased with the increasing temperature of all four binary solvent systems at the constant solvent composition, and the isopropyl acetate had a negative effect on the solubilities. The solubilities of clopidogrel hydrogen sulfate (form I) were correlated by the modified Apelblat, λh, and NRTL equations. The results indicated that the three models can predict the experimental values satisfactorily. Moreover, the modified Apelblat equation achieves the best fitting performance compared with other two models through calculating the value of average relative deviation.

Solubility Determination and Thermodynamic Correlation of 3-Amino-2-methylbenzoic Acid in 12 Monosolvents from 288.15 to 328.15 K

“…The modified Apelblat equation can fit the relationship between solubility and temperature, which is a semiempirical equation. 11,12 The mathematical expression of the equation can be described as follows…”

“…The modified Apelblat equation can fit the relationship between solubility and temperature, which is a semiempirical equation. , The mathematical expression of the equation can be described as follows in which x 1 is the mole fraction of 3-amino-2-methylbenzoic acid, T is the absolute experimental temperature, and A , B , and C are empirical constants …”

Solid–Liquid Equilibrium and Thermodynamic Properties of 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3]pyrimidin-7(8H)-one in 10 Pure Solvents and 3 Different Miscible Systems at T = (278.15–323.15) K

“…At the same time, it also shows that 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido [2,3]pyrimidin-7(8H)-one is not suitable for separation and purification in mixed solvents of similar polarity. 15 4.5. Solvent Effect on Solubility.…”

“…In this study, we used liquid chromatography to study the solubility of 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido- [2,3]pyrimidin-7(8H)-one in 10 pure solvents [dichloromethane, n-hexane, ethyl acetate, n-butyl alcohol, tetrahydrofuran (THF), ethyl alcohol, isopropanol, 1-propanol, dimethylformamide (DMF), and isophorone] and 3 mixed solvents (ethyl acetate + ethyl alcohol, isophorone + isopropanol, and THF + ethyl alcohol) from 278. 15 2. EXPERIMENTAL SECTION 2.1.…”

Solubility Measurement and Data Correlation of 4-Chlorophenoxyacetic Acid in 13 Monosolvents at Temperatures from 283.15 to 328.15 K

“…4-CPA is usually obtained by cooling crystallization. , Thus, the crystallization process plays an important role in determining its quality such as its purity, crystal habit, and particle size distribution. , The solubility data in different solvents can provide significant support for the design and optimization of the crystallization process such as the selection of a crystallization method and a solvent. − Furthermore, solubility data can also provide basic parameters for the further scientific research of 4-CPA, which makes it of great significance. However, most research studies on 4-CPA focus on its synthesis and applications and there is no detailed report on its solubility in different monosolvents.…”