Solubility Measurement and Stability Study of Sodium Cefuroxime

Liu, Wen J.; Cai, Yaqi; Feng, Sheng X.; Wang, Xue Z.

doi:10.1021/je400938a

Cited by 7 publications

(12 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, comparing with the stability test (3, 5, 7, and 10 days), XRD spectra can be measured quickly and gives direct evidence of the process optimization. Three sharp peaks of the XRD spectra of sodium cefuroxime were observed at 2 θ values of 9°–10.5°, 10.5°–13°, and 14°–15° . The peak intensity and peak width at half height of peak between 9° and 10.5° were chosen to present the crystallinity of sodium cefuroxime for quantification in this study.…”

Section: Resultsmentioning

confidence: 99%

“…In the storage and transportation processes, it tends to deepen solid color, reduce solubility, and become sticky . In our previous paper, cefuroxime sodium has only one polymorphic form and exists as a mixture of crystal and amorphous state. The general view is that the stability of drugs in the amorphous form is usually lower than the crystalline form, because of the higher free energy level under the amorphous form.…”

Section: Materials and Experimentsmentioning

confidence: 99%

“…Therefore, a replaced reactant, D‐7‐ACA (Deacetyl 7‐ACA) was used in this study, which is more environmentally friendly and can further improve the recovery ratio of the product. As a prerequisite work, the solubility of sodium cefuroxime has been measured in our previous study . The reaction stoichiometric equation can be seen as follows:

…”

Section: Materials and Experimentsmentioning

confidence: 99%

“…After 24 h vacuum drying in the DZF‐6030B vacuum oven, the final product was obtained. The seeds, sodium cefuroxime crystals (C 16 H 15 N 4 NaO 8 S, 446.37 kg mol −1 , >92%, water content <0.24%), was produced by an antisolvent recrystallization process . Ethanol (95% v/v) and activated carbon were obtained from Fisher Scientific, UK, acetone was obtained from Sigma, and the distilled water produced in our own laboratory was also used in this reactive crystallization process.…”

Section: Materials and Experimentsmentioning

confidence: 99%

See 3 more Smart Citations

Analytical technology aided optimization and scale‐up of impinging jet mixer for reactive crystallization process

et al. 2014

Self Cite

View full text Add to dashboard Cite

Reactive crystallization is widely used in the manufacture of active pharmaceutical ingredients (APIs). Since APIs often have low solubility, traditional stirred tank reactors and the route of process operation and control using metastable zone width are not effective. The current work investigated the integration of an impinging jet mixer and a stirred tank crystallizer that can take advantage of both the reaction and crystallization characteristics, the focus being on design optimization and scale-up using process analytical techniques based on the Fourier transform Infrared spectroscopy and Focused Beam Reflectance Measurement, as well as X-ray diffraction and particle imaging Morphologi G3. The parameters for process operation and design of the impinging jet mixer were optimized. The research was carried out with reference to the manufacture of an antibiotic, sodium cefuroxime, firstly in a 1L reactor, then a 10L reactor. The crystals produced showed higher crystallinity, narrower size distribution, higher stability and purity.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Materials and Experimentsmentioning

confidence: 99%

…”

Section: Materials and Experimentsmentioning

confidence: 99%

Section: Materials and Experimentsmentioning

confidence: 99%

See 2 more Smart Citations

Analytical technology aided optimization and scale‐up of impinging jet mixer for reactive crystallization process

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…It was also found that sodium cefuroxime is insoluble in acetone [8]. However, there was research focused on neither the influence of pH value on solubility of sodium cefuroxime nor provided any data.…”

Section: Solubility Of Sodium Cefuroximementioning

confidence: 99%

Novel Impinging Jet and Continuous Crystallizer Design for Rapid Reactive Crystallization of Pharmaceuticals

Liu

Cai

Wang

2015

Procedia Engineering

Self Cite

View full text Add to dashboard Cite

Reactive crystallization is an important operation in the pharmaceutical industry for the production of the active pharmaceutical ingredients (APIs), but has not been as widely studied as cooling or anti-solvent crystallization. Reactive crystallization has many unique features that make them different from cooling or anti-solvent crystallization, even leading to some concepts and methods not directly applicable to the former. Literature survey reveals that previous research on reactive crystallization has mainly been conducted for inorganic materials which are known to be simpler than crystallization of organic molecules. The focus of this research project was to carry out research on the process design and optimization of organic reactive crystallization. The objective was to research on novel crystallizer designs that suit and take advantages of the features of reactive crystallization, and on advanced modeling and optimization techniques with the aim of manufacturing high quality products. Process analytical technology was used as a supporting tool to achieve the above stated objectives. The results showed that by using novel impinging jet design, the product had uniform size distribution and superior crystallinity. In addition, continuous process design can achieve a greater amount of product handling and reduce the batch-to-batch variation.

show abstract

Continuous reactive crystallization of pharmaceuticals using impinging jet mixers

et al. 2016

Self Cite

View full text Add to dashboard Cite

For reactive crystallization of pharmaceuticals that show rapid reaction rate, low solubility of active pharmaceutical ingredient, hence large supersaturation, it was found in a recent study that a process design that integrates an impinging jet mixer and a batch stirred tank, the former to achieve intensive micromixing prior to reaction and crystal nucleation and the later to immediately disperse the formed nuclei or small particles to minimise aggregation but promote crystal growth, has produced high quality crystals. The current investigation studies the hypothesis that due to the short processing time of reactive crystallization, the impinging jet mixer -stirred tank design can be made to operate in continuous mode. The new design combines an impinging jet mixer for feed introduction and reaction, and a continuous stirred tank reactor (CSTR) and a tubular reactor for crystal growth. Study on reactive crystallization of sodium cefuroxime (an antibiotic), using firstly in a 1L CSTR then scaled to 50L CSTR, found that the new design has produced crystals of higher crystallinity, narrower particle size, and improved product stability, than the conventional batch crystallizer.

show abstract

Solubility Measurement and Stability Study of Sodium Cefuroxime

Cited by 7 publications

References 12 publications

Analytical technology aided optimization and scale‐up of impinging jet mixer for reactive crystallization process

Analytical technology aided optimization and scale‐up of impinging jet mixer for reactive crystallization process

Novel Impinging Jet and Continuous Crystallizer Design for Rapid Reactive Crystallization of Pharmaceuticals

Continuous reactive crystallization of pharmaceuticals using impinging jet mixers

Contact Info

Product

Resources

About