Solubility of 2,4,7-Triamino-6-phenylpteridine (Triamterene, Diuretic Drug) in Supercritical Carbon Dioxide: Experimental Data and Modeling

Abstract

In order to design and perform the processes of nano- and microparticle production via supercritical carbon dioxide (SC-CO2), solubility data information of a solid solute such as a pharmaceutical component in SC-CO2 is principally needed. Therefore, a drug solubility, 2,4,7-triamino-6-phenylpteridine (TRM), in SC-CO2 was determined at 308, 318, and 328 to 338 K from 12 to 27 MPa in the present study. Solubility in the mole fraction of TRM in SC-CO2 ranged between 0.42 × 10–5 and 1.83 × 10–5, 0.32 × 10–5 and 2.13 × 10–5, 0.09 × 10–5 and 2.34 × 10–5, and 0.03 × 10–5 and 2.89 × 10–5 at 308, 318, 328, and 338 K, respectively. According to the results, solubility data had correlation to the Peng–Robinson equation of state along with two parameters of van der Waals mixing rules and with models proposed by Méndez-Santiago and Teja, reformulated Charstil, Garlapati and Madras, Bian et al., Chrastil, Bartle et al., Sodeifian et al., and Tippana and Garlapati. It was found that correlation constants were temperature-independent in each model. Further, thermodynamic parameters such as heat of reaction, sublimation, and solvation of the compound were estimated.

Measurement and modeling of clemastine fumarate (antihistamine drug) solubility in supercritical carbon dioxide

“…For temperature independent regression suitable sublimation expression is used. The general form 34 , 35 used for the regression purpose is …”

“…The model has two parameters and . K.-W. Chen et al 35 , used the following temperature dependent general form 36 in place of …”

Measurement and Modeling of Clemastine Fumarate (Antihistamine Drug) Solubility in Supercritical Carbon Dioxide

“…For temperature independent regression a suitable sublimation expression is used. The general form 44,45 used for the regression purpose is…”

Solubility of Anthraquinone Derivatives in Supercritical Carbon Dioxide: New Correlations

“…Anthraquinone derivatives are majorly used in dyeing industries—the exact prediction of solubility data are very much essential for the development of supercritical dyeing process. There are five frameworks through which solubility data are analyzed [ 3 ]. Out of five approaches, thermodynamic frameworks based on solid–gas equilibrium criteria and solid–liquid equilibrium criteria are very successful [ 4 ].…”