Solubility of Airborne Uranium Compounds at the Fernald Environmental Management Project

Heffernan, T.E.; Lodwick, Jeffrey; Spitz, Henry B.; Neton, J.; Soldano, M.

doi:10.1097/00004032-200103000-00008

Cited by 11 publications

(3 citation statements)

References 10 publications

(6 reference statements)

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“…DU munitions, DU shrapnel, and the uranium oxides that form upon burning will dissolve in the environment [9, 24], in simulated gastrointestinal fluid [25], and in vivo [14, 15, 26]. Therefore, understanding the toxicology of soluble uranium may provide relevant insight into all long-term uranium exposures.…”

Section: Introductionmentioning

confidence: 99%

Analysis of heat-labile sites generated by reactions of depleted uranium and ascorbate in plasmid DNA

et al. 2013

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The goal of this study was to characterize how depleted uranium (DU) causes DNA damage. Procedures were developed to assess the ability of organic and inorganic DNA adducts to convert to single strand breaks (SSB) in pBR322 plasmid DNA in the presence of heat or piperidine. DNA adducts formed by methyl methanesulfonate (MMS), cis-platin (cis-Pt), and chromic chloride were compared to those formed by reaction of uranyl acetate (UA) and ascorbate (Asc). Uranyl ion in the presence of Asc produced U-DNA adducts that converted to SSB upon heating. Piperidine, which acted on DNA methylated by MMS to convert methyl-DNA adducts to SSB, served in the opposite fashion with U-DNA adducts by decreasing SSB. The observation that piperidine also decreased the gel shift for metal-DNA adducts formed by monofunctional cis-Pt and chromic chloride was interpreted to suggest that piperidine served to remove U-DNA adducts. Radical scavengers did not affect formation of U-induced SSB, suggesting that SSB arose from the presence of U-DNA adducts and not from free radicals. A model is proposed to predict how U-DNA adducts may serve as initial lesions that convert to SSB or AP sites. Results suggest that DU can act as a chemical genotoxin that does not require radiation for its mode of action. Characterizing the DNA lesions formed by DU is necessary to assess the relative importance of different DNA lesions in the formation of DU-induced mutations. Understanding mechanisms of formation of DU-induced mutations may contribute to identification of biomarkers of DU exposures in humans.

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Section: Introductionmentioning

confidence: 99%

Analysis of heat-labile sites generated by reactions of depleted uranium and ascorbate in plasmid DNA

et al. 2013

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“…The analysis of raw XAS data was performed in the ATHENA software. Each scan was deglitched and aligned and several scans (2)(3) were merged to improve signal-to-noise ratio. Merged spectra were treated carefully to set the correct pre-edge and post-edge lines, E 0 position.…”

Section: Methodsmentioning

confidence: 99%

Uranium oxides structural transformation in human body liquids

Poliakova

Krot²,

Trigub³

et al. 2023

Sci Rep

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Uranium oxide microparticles ingestion is one of the potential sources of internal radiation doses to the humans at accidental or undesirable releases of radioactive materials. It is important to predict the obtained dose and possible biological effect of these microparticles by studying uranium oxides transformations in case of their ingestion or inhalation. Using a combination of methods, a complex examination of structural changes of uranium oxides in the range from UO2 to U4O9, U3O8 and UO3 as well as before and after exposure of uranium oxides in simulated biological fluids: gastro-intestinal and lung—was carried out. Oxides were thoroughly characterized by Raman and XAFS spectroscopy. It was determined that the duration of expose has more influence on all oxides transformations. The greatest changes occurred in U4O9, that transformed into U4O9-y. UO2.05 and U3O8 structures became more ordered and UO3 did not undergo significant transformation.

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“…A number of studies have reported the use of SILF to investigate the release properties of inhaled drug formulations due to its close replication of the mucosal fluids present in the respiratory system (Gupta and Ahsan 2011;Costabile et al 2015;Pellosi et al 2018). Others have employed SILF to investigate the solubility of airborne U compounds (Heffernan et al 2001) and asbestos (Vigliaturo et al 2018). Two analogous studies investigated the effect of adding organic components to the SILF composition, namely bovine lung extract and DPPC.…”

Section: Simulated Interstitial Fluid (Silf)mentioning

confidence: 99%

Simulated biological fluids – a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres

Innes

Yiu

McLean

et al. 2021

Critical Reviews in Toxicology

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Solubility of Airborne Uranium Compounds at the Fernald Environmental Management Project

Cited by 11 publications

References 10 publications

Analysis of heat-labile sites generated by reactions of depleted uranium and ascorbate in plasmid DNA

Analysis of heat-labile sites generated by reactions of depleted uranium and ascorbate in plasmid DNA

Uranium oxides structural transformation in human body liquids

Simulated biological fluids – a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres

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