Solubility of Benzoic Acid and Aspirin in Pure Solvents Using Focused Beam Reflective Measurement

Tully, Gavin; Hou, Guangyang; Glennon, Brian

doi:10.1021/acs.jced.5b00746

Cited by 17 publications

(17 citation statements)

References 30 publications

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“…In summary, MAAC provides a promising approach to equip smaller separation units with high mass transfer area and simple devices, which sheds light on opportunities for its use in chemical production in limited spaces, such as mini chemical or pharmaceutical plants …”

Section: Resultsmentioning

confidence: 99%

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

et al. 2018

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Herein, a novel hollow fiber membrane‐assisted antisolvent crystallization (MAAC) was proposed to enhance the mass transfer control over the antisolvent crystallization. A polyethersulfone membrane module was introduced as the key device for antisolvent transfer and solution mixing. An antisolvent liquid film layer was formed on the membrane surface and mixed with the solution. The liquid film also prevented the membrane from directly contacting with crystallization solution. By controlling both the shell side flow velocity and the antisolvent transfer, the antisolvent permeation rate achieved sensitive, stable, and accurate control during long‐term and repeated utilization. The interfacial mass transfer rate of MAAC was 0.66 mg cm−2 s−1, which was only 1/50 that of conventional droplet antisolvent crystallization. MAAC also provided crystal products with better morphologies and narrower size distributions than the conventional process. The stable performances of MAAC in terms of its accurate antisolvent mass transfer and antifouling capabilities were also highlighted. © 2018 American Institute of Chemical Engineers AIChE J, 65: 734–744, 2019

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Section: Resultsmentioning

confidence: 99%

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

et al. 2018

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“…Phospholipid and surfactant interfaces have hydrophobic and hydrophilic components and, since, HB is able to dissolve in both organic nonpolar solvents as well as water, 16 it should readily traverse the membrane. 17,18 The interaction of HB with a surfactant interface was previously studied using both cationic and anionic micelles.…”

Section: Introductionmentioning

confidence: 99%

Differences in Interactions of Benzoic Acid and Benzoate with Interfaces

et al. 2016

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The interaction of benzoic acid and benzoate with model membrane systems was characterized to understand the molecular interactions of the two forms of a simple aromatic acid with the components of the membrane. The microemulsion system based on bis(2ethylhexyl)sulfosuccinate (AOT) allowed determination of the molecular positioning using 1D NMR and 2D NMR spectroscopic methods. Benzoic acid and benzoate were both found to penetrate the membrane/water interfaces; however, the benzoic acid was able to penetrate much deeper and thus is more readily able to traverse a membrane. The Langmuir monolayer model system, using dipalmitoylphosphatidylcholine, was used as a generic membrane lipid for a cell. Compression isotherms of monolayers demonstrated a pH dependent interaction with a lipid monolayer and confirming the pH dependent observations shown in the reverse micellar model system. These studies provide an explanation for the antimicrobial activity of benzoic acid while benzoate is inactive. Furthermore, these studies form the framework upon which we are investigating the mode of bacterial uptake of pyrazinoic acid, the active form of pyrazinamide, a front line drug used to combat tuberculosis.

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“…Similarly, the solubility of mefenamic acid is known to be several orders of magnitude smaller in water than in organic solvents [5,16]. In the inset of benzoic acid [92], diphenylamine [89], and mefenamic acid [16] in ethyl acetate. found in the literature for the solid-liquid [95,83] , liquid-liquid [95,96], and vapour-liquid [100] equilibria.…”

Section: Solid-liquid Solubility Phase Diagramsmentioning

confidence: 99%

“…The triangles represent the experimental results presented in our work. The squares represent the solubility measured in previous work and found in the literature, for (a) benzoic acid in acetone[93], mefenamic acid in acetone[16], and (b) benzoic acid in butan-2-one[92].…”

mentioning

confidence: 99%

Extending the SAFT-γ Mie approach to model benzoic acid, diphenylamine, and mefenamic acid: Solubility prediction and experimental measurement

Febra

Bernet

Mack

et al. 2021

Fluid Phase Equilibria

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Solubility of Benzoic Acid and Aspirin in Pure Solvents Using Focused Beam Reflective Measurement

Cited by 17 publications

References 30 publications

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

A novel hollow fiber membrane‐assisted antisolvent crystallization for enhanced mass transfer process control

Differences in Interactions of Benzoic Acid and Benzoate with Interfaces

Extending the SAFT-γ Mie approach to model benzoic acid, diphenylamine, and mefenamic acid: Solubility prediction and experimental measurement

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