Solubility of Butanedioic Acid in Different Solvents at Temperatures between 283 K and 333 K

Abstract

Using a laser monitoring observation technique, the solubilities of butanedioic acid in water, ethanol, 1-propanol, 2-propanol, acetone, and ethanoic acid were determined by the synthetic method at temperatures between 283 K and 333 K. A laser technique is used to determine the disappearance of solute particles. The experimental data can be well correlated by a semiempirical equation.

Enthalpy of solvation correlations for organic solutes and gases dissolved in 2-propanol, 2-butanol, 2-methyl-1-propanol and ethanol

“…14 Our search of the chemical and engineering literature also found recently published solubility data for adipic acid [20], sebacic acid [21], pimelic acid [22], azelaic acid [23] and succinic acid [24] in ethanol as a function of temperature that could be combined with published enthalpy of sublimation data [112,113] …”

“…], adipic acid [20], succinic acid [24] and sebacic acid [110] were calculated from the variation of mole fraction solubility with temperature. The ΔH soln values were converted to gas- Tables S1 -S3 (Supplementary Material) along with the values of the solute descriptors of the compounds considered in the present study.…”

Experimental and Computational Methods Pertaining to Drug Solubility

“…The synthetic method (Hankinson and Thompson, 1965;Ren et al, 2005;Yang et al, 2008;Yu et al, 2009) which is so called laser monitoring technique (Li et al, 2006), last crystal disappearance method (Hao et al, 2005) and dynamic method (Peisheng and Qing, 2001;Weiwei et al, 2007;Wang et al, 2008) is based on disappearance of the solid drug (from the mixture of solvent and drug) monitored by a laser beam. The history of this method backs to 1886 and first introduced by Alexejew and then modified by other research groups (Ward, 1926).…”

Enthalpy of solvation correlations for organic solutes and gases dissolved in 1-propanol and tetrahydrofuran

“…anthracene [156], acenaphthene [157], adipic acid [158], succinic acid [159] and sebacic acid [160] were calculated from the variation of mole fraction solubility with temperature. The ΔH soln values were converted to gas-to-organic solvent enthalpies of transfer by…”