Solubility of capsaicin in dense CO2

Knez, Željko; Steiner, Rudolf

doi:10.1016/0896-8446(92)90015-c

Cited by 39 publications

(24 citation statements)

References 5 publications

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“…The phase equilibrium measurements were carried out in the same high-pressure vessel apparatus used for the bio-reaction tests. Analogous experimental procedure and apparatus were proposed by Knez and co-workers elsewhere (Škerget et al, 1995;Knez and Steiner, 1992). Equilibrium data of the studied system was experimentally determined at 323.15 K over a pressure range from 1 to 27 MPa.…”

Section: Phase Equilibrium Measurementsmentioning

confidence: 99%

Exploiting the pressure effect on lipase‐catalyzed wax ester synthesis in dense carbon dioxide

Knez

Laudani

Habulin

et al. 2007

Biotech & Bioengineering

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The present work focuses on the thermodynamic interpretation of the lauryl oleate biosynthesis in high-pressure carbon dioxide. Lipase-catalyzed lauryl oleate production by oleic acid esterification with 1-dodecanol over immobilized lipase from Rhizomucor miehei (Lipozyme RM IM) was successfully performed in a sapphire window batch stirred tank reactor (BSTR) using dense CO(2) as reaction medium. The experiments were planned to elucidate the pressure effect on the reaction performance. With increasing the pressure up to 10 MPa, the catalytic efficiency of the studied enzyme improved rising up to a maximum and decreased at higher pressure values. Kinetic observations, exhibiting that dense CO(2) expanded reaction mixture in subcritical conditions led to higher performance than when diluted in a single supercritical phase, were elucidated by phase-equilibrium arguments. The experimental results were justified with emphasis on thermodynamic interpretation of the studied system. Particularly, the different reaction performances obtained were related to the position of the operating point with respect to the location of liquid-vapor phase boundaries of the reactant fatty acid/alcohol/CO(2) ternary system. The outlook for exploitation of CO(2) expanded phase at lower pressure compared to supercritical phase, with heterogeneous system in which the solid catalyst particles are exposed to dense CO(2) expanded reaction mixture, in developing new biotransformation schemes is promising.

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Section: Phase Equilibrium Measurementsmentioning

confidence: 99%

Exploiting the pressure effect on lipase‐catalyzed wax ester synthesis in dense carbon dioxide

Knez

Laudani

Habulin

et al. 2007

Biotech & Bioengineering

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“…We did not find any work in the literature related to the binary solubilities studied in this work, although pure compound solubilities of α-tocopherol, ,− capsaicin, − or palmitic acid − in supercritical CO 2 have been already reported in the literature. The characteristics of these works are summarized in Table .…”

Section: Introductionmentioning

confidence: 84%

Solubilities of Binary Systems α-Tocopherol + Capsaicin and α-Tocopherol + Palmitic Acid in Supercritical Carbon Dioxide

et al. 2019

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Solubilities of two binary mixtures (α-tocopherol + capsaicin and α-tocopherol + palmitic acid) in supercritical carbon dioxide (CO2) are reported in this work. Measurements were done in a semiflow apparatus at 308.15 and 328.15 K and in the pressure interval from 10 to 35 MPa. Equimolar mixtures of the solutes were prepared to perform solubility measurements. Each solubility point was replicated at least three times to check for the repeatability. Solubilities of α-tocopherol were higher than those of capsaicin for the ternary system. Meanwhile, for the binary mixtures α-tocopherol + palmitic acid, their solubilities in supercritical CO2 suffered a shift as temperature increased. The solubility of α-tocopherol was higher than that of palmitic acid at 308.15 K, and the vice versa occurred at 328.15 K. Solubilities were modeled by means of the Peng–Robinson equation of state using the van der Waals mixing rules with two adjustable parameters. Additionally, The Kumar and Johnston model was selected for the empirical correlation.

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“…Samples were taken out of the reactor during the reaction (same method as in Ref. 46), and the amount of free oleic acid was determined.…”

Section: Methodsmentioning

confidence: 99%

Enzymatic synthesis of oleyl oleate in dense fluids

Knez

Rižner

Habulin

et al. 1995

J Americ Oil Chem Soc

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Esterification between oleic acid and oleyl alcohol, catalyzed by the Mucor miehei immobilized lipase in a batch-stirred tank reactor with supercritical carbon dioxide as solvent produced higher reaction rates at supercritical conditions than in the solvent-free system. A continuous fixed-bed reactor was designed based on the results obtained from batch experiments. At 150 bar, 40°C, and with water activity 0.46% w/w, the activity of the enzyme preparation is practically unchanged when CO 2 was used as solvent. The addition of small amounts of water increases the conversion rate. The higher conversion also was observed at longer residence time. When nbutane was used as reaction medium, a decrease in conversion was observed. JAOCS 72, 1345-1349 (1995).

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Solubility of capsaicin in dense CO2

Cited by 39 publications

References 5 publications

Exploiting the pressure effect on lipase‐catalyzed wax ester synthesis in dense carbon dioxide

Exploiting the pressure effect on lipase‐catalyzed wax ester synthesis in dense carbon dioxide

Solubilities of Binary Systems α-Tocopherol + Capsaicin and α-Tocopherol + Palmitic Acid in Supercritical Carbon Dioxide

Enzymatic synthesis of oleyl oleate in dense fluids

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