Solubility of Cefotaxime Sodium Salt in Seven Solvents Used in the Pharmaceutical Industry

Abstract

The solubility of cefotaxime sodium salt (sodium (7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]cephalosporanate) in methanol, ethanol, acetone, n-hexane, dichloromethane, diethyl ether, and ethyl acetate in the temperature range from 5 to 40 °C was determined.

A Practical Approach for Using Solubility to Design Cooling Crystallisations

“…To get a better understanding of typical crystallisation yields for cooling crystallisations we evaluated the parameters in eq for 93 systems in the literature. – For all these systems the heat of fusion, the melting point, and temperature-dependent solubility data were available in a number of solvents or solvent mixtures. In addition to these data we analysed 20 AstraZeneca systems based on 9 AstraZeneca compounds for which data could not be revealed.…”

Adsorption of Benzenesulfonic Acid; 3,3‘,3‘ ‘-Phosphinidynetris-, Trisodium Salt; and Di(μ-tertiobutylthiolato) Dicarbonyl, Bis(benzenesulfonic acid, 3,3‘,3‘ ‘-phosphinidynetris-, Trisodium Salt) Dirhodium from Aqueous Solutions on Silica

“…The solubility studies were carried out as described elsewhere. 6,7 The mass of solid was chosen to be in small excess relative to the highest estimated solubility in the In adsorption experiments, a fixed amount of silica (0.5 g) and 6 cm 3 of an aqueous solution of TPPTS or [Rh(µ-St Bu)(CO)(TPPTS)] 2 were placed in a 50 cm 3 glass-stoppered flask and shaken at 100 rpm for 24 h in a thermostated oscillating bath (JULABO-SW-20C). The aqueous solutions of TPPTS and [Rh(µ-S t Bu)(CO)(TPPTS)] 2 were prepared in deaerated water.…”

“…The solubility studies were carried out as described elsewhere. , The mass of solid was chosen to be in small excess relative to the highest estimated solubility in the chosen amount of water. The content of the vessel was stirred at 100 rpm.…”