Solubility of Diflufenican in Pure and Binary Solvent Systems

Abstract

With the aid of a laser monitoring technique, the solution thermodynamics of diflufenican was sysmatically studied in the pure and binary solvent systems. The solubility screening results showed that diflufenican had excellent solubility in ethyl acetate, acetone, benzene, and toluene which could be used as good solvents. While methanol, ethanol, isopropyl alcohol and cyclohexane were the poor solvents for diflufenican as the solubility was quite small. Two binary solvent systems (acetone + water, acetone + ethanol) were composed, which exhibited a wide solubility range of diflufenican. The solubility data were well correlated by the modified Apelblat model, NRTL model, van't Hoff model, λh model, and Jouyban−Acree model, which provided the basis for the design and optimization for the diflufenican crystallization process.

Solubility and Thermodynamic Modeling of Sulfanilamide in 12 Mono Solvents and 4 Binary Solvent Mixtures from 278.15 to 318.15 K

“…Based on the condition of a dilute solution which is approximately considered as an ideal solution, the van’t Hoff model was derived. Then, the nonrandom two liquid equation becomes as a function of temperature shown in eq when the activity coefficient equals to 1; eq was the simplified form of eq . − , where x represents the mole fraction solubility of sulfanilamide in solvents; T refers to absolute temperature; and a and b are the van’t Hoff parameters determined by solubility fittings.…”

Diflufenican Dissolved in Different Aqueous Cosolvency Mixtures: Equilibrium Solubility Measurement and Thermodynamic Modeling

“…Before us, Song et al have done some research on the dissolution behavior and thermodynamic properties of diflufenican. 16 But their research direction focuses on the dissolution of solutes in a single solvent, and the research on mixed systems is not extensive, so the research in this experiment is still necessary. The research object this time has overlapped with the work of the predecessors, that is, the mole fraction of diflufenican in pure ethanol.…”

“…The Jouyban–Acree model as the basis of the three models is very representative and the most classic model and can be described as eq . ,− where, x w,T represents the diflufenican’ mole fraction at T ; w 1 and w 2 are the mass fractions of the cosolvents; x 1,T and x 2,T are the diflufenican solubilities in neat solvents; and J i are the parameters.…”

“…Meanwhile, the above used solvents are toxic and difficult to recover. Song et al 16 studied the diflufenican solubility in some pure and binary solvents and thought the water as a good antisolvent.…”

Solubility Measurement of Crystal Form II and Form V Ticagrelor in Several Pure Organic Solvents

“…The λ h model was developed by Buchowski et al − The model can be expressed as the following expression. where x refers to the mole fraction solubility of the solute; T and T m are the temperature and the melting point of the solute, respectively; and λ and h are the model parameters.…”