Solubility of Fenofibrate in Different Binary Solvents: Experimental Data and Results of Thermodynamic Modeling

Sun, Hua; Liu, Bao‐Shu; Liu, Peihua; Zhang, Junli; Wang, Yongli

doi:10.1021/acs.jced.6b00268

Cited by 21 publications

(25 citation statements)

References 33 publications

(49 reference statements)

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“…The final functions were obtained as follows:normalΔHsol=RT(C−BT),normalΔSsol=Rfalse(A+C+ClnTfalse)2emand2emnormalΔGsol=−RT(A+BT+ClnT),where A , B and C are the parameters gained from the modified Apelblat model (tables 2 and 4). The mean temperature T was defined by the following equation for minimizing the error propagation [29,30]:T=N∑false(1/Tifalse),where N is the number of temperature points measured in the experiment.…”

Section: Resultsmentioning

confidence: 99%

Solubility of dicarbohydrazide bis[3-(5-nitroimino-1,2,4-triazole)] in common pure solvents and binary solvents at different temperatures

Ren

Chen

et al. 2019

R. Soc. open sci.

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The solubility of dicarbohydrazide bis[3-(5-nitroimino-1,2,4-triazole)] (DCBNT) was first measured under the different pure solvents and binary solvents by the dynamic method over the temperature range of 290–360 K at atmospheric pressure. Results in all the solvents were positively correlated with temperature, namely increased with increasing temperature. The experiment data were correlated by the Apelblat equation, the Yaws equation and the polynomial equation. The conclusion showed that these three models all agreed well with the experimental data. Simultaneously, the dissolution enthalpy, dissolution entropy and Gibbs free energy of DCBNT in different solvents were calculated from the solubility data by using the Apelblat model. The results indicate that the dissolution process of DCBNT in these solvents is driven by entropy, which provides theoretical guidance for further research on the crystallization of DCBNT.

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Section: Resultsmentioning

confidence: 99%

Solubility of dicarbohydrazide bis[3-(5-nitroimino-1,2,4-triazole)] in common pure solvents and binary solvents at different temperatures

Ren

Chen

et al. 2019

R. Soc. open sci.

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“…The method verification was performed in previous works. [2,[6][7][8][9][10] The equipment and method for the determination of supersolubility were similar with those for solubility. In the process of supersolubility determination, phenylacetyl-7-ADCA and mixed solvents with determined masses was added to the vessel and heated to obtain clear solution.…”

Section: Solubility and Supersolubility Of Phenylacetyl-7-adcamentioning

confidence: 97%

“…A laser monitoring observation technique was used to determine the solubility of phenylacetyl-7-ADCA. [2,[6][7][8][9] The measuring apparatus is shown in Figure 2. The materials were dissolved in a glass jacketed vessel with a volume of 100 mL.…”

Section: Solubility and Supersolubility Of Phenylacetyl-7-adcamentioning

confidence: 99%

“…The solubility and supersolubility of phenylacetyl-7-ADCA in the water-ethanol system with different mole ratios were determined, providing data to support the recrystallization process. [2,[6][7][8][9] Two recrystallization processes, cooling recrystallization and antisolvent recrystallization, were developed on the basis of the water-ethanol system. The operating conditions of recrystallization were investigated by a single factor experiment.…”

Section: Introductionmentioning

confidence: 99%

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Preparation Process and Growth Mechanism Analysis of Phenylacetyl‐7‐Aminodeacetoxycephalosporanic Acid Crystals with Controllable Morphology

Han

Liu

Zhang

et al. 2020

Crystal Research and Technology

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A recrystallization process for phenylacetyl-7aminodeacetoxycephalosporanic acid (phenylacetyl-7-ADCA) is used to obtain the monoclinic and tetragonal crystal forms. The purity of the process product is 99.7%, which is much higher than the 97.1% of the raw material, while the median (D 50) particle size is larger (144 µm) and the diameter span (DS) is reduced from 10.478 (raw material) to 2.070 (new process product). The results show that in water-ethanol systems when the mole fraction of water is less than 0.5, the products obtained are long rod-shaped, while when the mole fraction of water is greater than 0.5, lamellar crystal products are obtained. The growth mechanism of phenylacetyl-7-ADCA with different habits is analyzed by Materials Studio molecular simulation software. The results show that a large number of oxygen and nitrogen atoms at both ends of the crystal are exposed to the crystal surfaces during the cooling recrystallization process and it is easy to form hydrogen bonds with free phenylacetyl-7-ADCA. Therefore, the crystal surfaces at both ends grow fastest and tend to disappear eventually. This work may provide a preparation process and simulation method for phenylacetyl-7-ADCA crystals, which would help improve the quality of cephalosporins.

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“…Crystallization is an important method used for the production of medicine, allowing purity, crystal size distribution (CSD), and morphology to be optimized . Crystallization comprises the following two steps: phase formation, known as nucleation, and growth of the nuclei to form crystals.…”

Section: Introductionmentioning

confidence: 99%

Determination of Nucleation Kinetics of Cephradine in 0.5% Sodium Bisulfate (W/V) Solution

Sun

Jiang

Liu

2017

Crystal Research and Technology

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The metastable zone width of cephradine in a 0.5% sodium bisulfate (W/V) solution was determined at different values of pH and temperatures by using dynamic laser monitoring under atmospheric pressure. As the pH increased, the metastable zone width of cephradine decreased before increasing, with a minimum value at the isoelectric point. The effect of temperature was less pronounced. The induction periods of cephradine in the 0.5% sodium bisulfate (W/V) solution were investigated as a function of the supersaturation ratio. By applying classical homogeneous nucleation theory, we deduced the crystal-liquid interfacial tension and the following fundamental nucleation parameters: the Gibbs free energy change for the formation of the critical nucleus, the radius of the critical nucleus, and the number of molecules in the critical nucleus.

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Solubility of Fenofibrate in Different Binary Solvents: Experimental Data and Results of Thermodynamic Modeling

Cited by 21 publications

References 33 publications

Solubility of dicarbohydrazide bis[3-(5-nitroimino-1,2,4-triazole)] in common pure solvents and binary solvents at different temperatures

Solubility of dicarbohydrazide bis[3-(5-nitroimino-1,2,4-triazole)] in common pure solvents and binary solvents at different temperatures

Preparation Process and Growth Mechanism Analysis of Phenylacetyl‐7‐Aminodeacetoxycephalosporanic Acid Crystals with Controllable Morphology

Determination of Nucleation Kinetics of Cephradine in 0.5% Sodium Bisulfate (W/V) Solution

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