Solubility of fluorocarbons in water as a key parameter determining fluorocarbon emulsion stability

Kabalnov, Alexey; Makarov, K. N.; Shcherbakova, Olga V; Nesmeyanov, A. N.

doi:10.1016/s0022-1139(00)84993-3

Cited by 55 publications

(37 citation statements)

References 19 publications

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“…The pre-existing bubbles grew upon heating as shown in Figure 2. There are at least three different mechanisms of bubble growth: (1) transition of the preserved liquid into the gaseous phase inside a confined particle space; (2) droplet/bubble coalescence or bubble coalescence; and (3) diffusion of dissolved air and/or PFP from small bubbles into larger bubbles (i.e., Oswald ripening) [28]. …”

Section: Resultsmentioning

confidence: 99%

Microbubble generation in phase-shift nanoemulsions used as anticancer drug carriers

Rapoport

Efros

Christensen

et al. 2009

Bubble Science, Engineering & Technology

109

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The paper describes droplet-to-bubble transition in block copolymer stabilized perfluoropentane nanoemulsions. Three physical factors that trigger droplet-to-bubble transition in liquid emulsions and gels were evaluated, namely heat, ultrasound, and injections through fine-gauge needles. Among those listed, ultrasound irradiation was found the most efficient factor. Possible mechanisms of bubble generation and growth discussed in the paper include liquid-to-gas transition inside the individual bubble; bubble coalescence; and diffusion of dissolved air and/or perfluoropentane from small bubbles into larger bubbles (i.e., Oswald ripening). The last two factors result in irreversibility of the droplet-to-bubble transition. In gel matrices, ultrasound-induced droplet-to-bubble transition was substantially inhibited but was catalyzed by large (hundred micron) pre-existing bubbles irradiated by low frequency (hundred kilohertz) ultrasound. The dependence of the droplet-to-bubble transition on initial bubble size is theoretically treated and the role of increase of surface area in promoting bubble coalescence is discussed. Therapeutic implications of observed effects are discussed.

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Section: Resultsmentioning

confidence: 99%

Microbubble generation in phase-shift nanoemulsions used as anticancer drug carriers

Rapoport

Efros

Christensen

et al. 2009

Bubble Science, Engineering & Technology

109

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show abstract

“…It has been shown that oils with high viscosity and low interfacial tension yield emulsions with smaller droplet size after homogenization [27]. [32][33][34] 6.6 × 10 −4 5.14 × 10 −3 2.94 × 10 −4 Interfacial tension a (N m −1 ) [30,35] 0.05720 0.05661 0.0497 Water solubility (mol L −1 ) [36,37] 2.7 × 10 −7 9.9 × 10 −9 1.430 × 10 −4 Diffusion coefficient a (m 2 s −1 ) [38] 6.79 × 10 −10 6.34 × 10 −10 9.97 × 10 −10 Ostwald ripening rate a (mol s −1 )…”

Section: Resultsmentioning

confidence: 99%

Aging mechanisms of perfluorocarbon emulsions using image analysis

Freire

Dias

Coelho

et al. 2005

Journal of Colloid and Interface Science

116

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“…PFCs are practically insoluble in water [37] and vice versa [38]. For example, the solubility of water in typical PFCs ranges from approximately 10 -6 to 10 -10 mol/l [39]. Furthermore, PFCs are poorly soluble in typical organic solvents [40], as well as biological lipids and fats.…”

Section: Properties Of Aliphatic Pfc Compoundsmentioning

confidence: 99%

Anti-inflammatory effects of perfluorocarbon compounds

Lehmler¹

2008

Expert Review of Respiratory Medicine

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Perfluorocarbon compounds (PFCs) are of interest for the treatment of acute lung injury due to unique physicochemical properties such as high solubility for oxygen. Different respiratory treatment modalities (e.g., liquid ventilation or aerosolized PFCs) have been shown to decrease pulmonary inflammatory responses in addition to improving lung compliance in animal models of lung injury and in clinical trials. Specifically, PFC-based treatment modalities have been shown to reduce levels of cytokines, chemokines and other mediators of pulmonary inflammation in a PFC- and, to some extent, concentration-dependent manner. As a result, neutrophil adhesion, accumulation and activation are reduced in PFC-treated animals and in humans undergoing partial liquid ventilation. Although more fundamental studies of the underlying anti-inflammatory mechanisms are needed, respiratory treatment modalities involving PFCs hold great clinical promise.

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Solubility of fluorocarbons in water as a key parameter determining fluorocarbon emulsion stability

Cited by 55 publications

References 19 publications

Microbubble generation in phase-shift nanoemulsions used as anticancer drug carriers

Microbubble generation in phase-shift nanoemulsions used as anticancer drug carriers

Aging mechanisms of perfluorocarbon emulsions using image analysis

Anti-inflammatory effects of perfluorocarbon compounds

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