“…A complete T – x phase diagram of a mannitol–water system is not readily available from the literature, while there are reports on various elements of the phase diagram, as follows. Temperature dependence of solubility of mannitol was reported in several publications, − although the solid form of mannitol was not confirmed. A mannitol solubility line has also been presented in a partial phase diagram; however, neither the mannitol form nor the source of the solubility data were provided, and therefore, these solubility data are not included in the current analysis.…”