Solubility of mesalazine in polyethylene glycol 400 + water mixtures at different temperatures

Experimental Study and Thermodynamic Modeling of Mesalamine and Azathioprine Solubility in Some Choline Chloride-Based Deep Eutectic Solvents

“…On the other hand, we compared the experimental mesalamine solubility data in water and DES2 with the literature data, − which has been given in Figures and and Tables S2 and S3. As can be seen, there is a good agreement between the present experimental data and those shown in the literature.…”

“…Experimental solubility of mesalamine in water; blue ●, literature data [ref ]; red ▲, literature data [ref ]; green ■, literature data [ref ]; pink *, literature data [ref ]; and black ◆, present study.…”

“…Azathioprine, an immunosuppressive antimetabolite, is practically insoluble in water and is mainly used to prevent the rejection of transplanted organs with other medications. It is also used to treat inflammatory bowel disease, ulcerative colitis, Crohn’s disease, and severe rheumatoid arthritis (a condition in which the body attacks its joints, causing pain, swelling, and loss of function). − Although the mesalamine and azathioprine solubility in some conventional solvents has been reported, − to the best of our knowledge, the reported experimental solubility data in DESs are so limited . Therefore, this study aims to investigate the mesalamine and azathioprine solubility in water, DES1, DES2, and their aqueous mixtures in the temperature range of 283.15–323.15 K. Figure demonstrates the chemical structure of mesalamine, azathioprine, and their constituents, HBA and HBD.…”

Solubility Data, Solubility Parameters and Thermodynamic Behavior of an Antiviral Drug Emtricitabine in Different Pure Solvents: Molecular Understanding of Solubility and Dissolution

“…The x e values of ECT were found highest in PEG-400 (1.41 × 10 −1 ), followed by EG (5.72 × 10 −2 ), THP (4.65 × 10 −2 ), PG (3.90 × 10 −2 ), methanol (1.49 × 10 −2 ), water (1.13 × 10 −2 ), IPA (8.19 × 10 −3 ), ethanol (7.76 × 10 −3 ), 1-butanol (6.84 × 10 −3 ), DMSO (6.59 × 10 −3 ), 2-butanol (6.55 × 10 −3 ) and EA (1.28 × 10 −3 ) at T = 318.2 K. In the present research, the impact of PEGs molar mass/polymerization on ECT solubility was not investigated because only PEG-400 was investigated in this research. In addition, PEG-400 is the most commonly used solubilizer among other grades of PEGs [ 16 , 21 , 22 ]. Nevertheless, the mole fraction solubility of drugs is known to be increased with increase in the molar mass of the solvents/co-solutes.…”

“…Accordingly, in the present research, the mole fraction solubility of ECT would be enhanced with increase in the molar mass of PEGs [ 23 ]. Due to extensive use of PEG-400 in solubility enhancement, this grade was selected in this research [ 21 , 22 ]. Overall, the solubility of ECT was found good in many PS including PEG-400, EG, THP, PG, methanol and water.…”