Solubility of methylphosphonic acid in selected organic solvents

Shao, Xianzhao; Ge, Hongguang; Li, Zhizhou; Ren, Chuan-Qing; Wang, Junhong

doi:10.1016/j.fluid.2015.01.009

Cited by 18 publications

(10 citation statements)

References 22 publications

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“…Glyphosate has been determined in the urine of humans at levels corresponding to a dietary daily intake of around 0.1–3.3 μg/kg bw/day [ 17 ]. High volumes of adjuvants (also called surfactants) are also used in herbicide preparations, and thus they (or their transformation products) are found in the environment [ 18 ] and food [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Glyphosate, Its Metabolites and Impurities on Viability, ATP Level and Morphological changes in Human Peripheral Blood Mononuclear Cells

et al. 2016

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The toxicity of herbicides to animals and human is an issue of worldwide concern. The present study has been undertaken to assess toxic effect of widely used pesticide—glyphosate, its metabolites: aminomethylphosphonic acid (AMPA) and methylphosphonic acid and its impurities: N-(phosphonomethyl)iminodiacetic acid (PMIDA), N-methylglyphosate, hydroxymethylphosphonic acid and bis-(phosphonomethyl)amine on human peripheral blood mononuclear cells (PBMCs). We have evaluated the effect of those compounds on viability, ATP level, size (FSC-A parameter) and granulation (SSC-A parameter) of the cells studied. Human peripheral blood mononuclear cells were exposed to different concentrations of glyphosate, its metabolites and impurities (0.01–10 mM) for 4 and 24 h. It was found that investigated compounds caused statistically significant decrease in viability and ATP level of PBMCs. The strongest changes in cell viability and ATP level were observed after 24 h incubation of PBMCs with bis-(phosphonomethyl)amine, and particularly PMIDA. Moreover, all studied compounds changed cell granularity, while PMIDA and bis-(phosphonomethyl)amine altered PBMCs size. It may be concluded that bis-(phosphonomethyl)amine, and PMIDA caused a slightly stronger damage to PBMCs than did glyphosate. Changes in the parameters studied in PBMCs were observed only at high concentrations of the compounds examined, which clearly shows that they may occur in this cell type only as a result of acute poisoning of human organism with these substances.

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Section: Discussionmentioning

confidence: 99%

The Impact of Glyphosate, Its Metabolites and Impurities on Viability, ATP Level and Morphological changes in Human Peripheral Blood Mononuclear Cells

et al. 2016

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“…In the VHM equation illustrated as in Equation (13), logarithm of mole fraction solubility of the solute is linearly correlated to the reciprocal of the absolute temperature in the ideal solution. It is a simplified expression of activity coefficient formula and expressed as [ 18 ]:

where T is the absolute temperature,

is mole fraction solubility of ABN401, and a and b are the model parameters.…”

Section: Methodsmentioning

confidence: 99%

“…Similarly, for TWM, modified the AM, VHM, Jouyhan–Acree van’t Hoff model (JAVHM), and Yalkowsky model (YM) were also used to correlate the experimental mole fraction solubility [ 2 , 11 ]. Apparent thermodynamic properties including Gibbs free energy change (

), enthalpy change (

), and entropy change (

) of the drug were calculated from the solubility data using VHM analysis for both organic solvents and binary mixed solvents [ 11 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

et al. 2021

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The solubility and dissolution thermodynamics of new c-Met inhibitor, ABN401, were determined in eleven solvents and Transcutol® HP–water mixture (TWM) from 298.15 to 318.15 K. The experimental solubilities were validated using five mathematical models, namely modified Apelblat, van’t Hoff, Buchowski–Ksiazaczak λh, Yalkowsky, and Jouyban–Acree van’t Hoff models. The experimental results were correlated and utilized further to investigate the feasibility of nanosuspension formation using liquid anti-solvent precipitation. Thermodynamic solubility of ABN401 increased significantly with the increase in temperature and maximum solubility was obtained with Transcutol® HP while low solubility in was obtained water. An activity coefficient study indicated that high molecular interaction was observed in ABN401–Transcutol® HP (THP). The solubility increased proportionately as the mole fraction of Transcutol® HP increased in TWM, which was also supported by a solvent effect study. The result suggested endothermic and entropy-driven dissolution. Based on the solubility, nanosuspension was designed with Transcutol® HP as solvent, and water as anti-solvent. The mean particle size of nanosuspension decreased to 43.05 nm when the mole fraction of ABN401 in THP, and mole fraction of ABN401 in TWM mixture were decreased to 0.04 and 0.1. The ultrasonicated nanosuspension appeared to give comparatively higher dissolution than micronized nanosuspension and provide a candidate formulation for in vivo purposes.

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“…4-5. Because of the lack of activity coefficients, in this work Gibbs energy of solution can just be determined as an apparent value. Thus, the equation of mole Gibbs energy is [18]: …”

Section: Thermodynamic Properties For the Solutionmentioning

confidence: 99%

Thermodynamic analysis and correlation of solid–liquid equilibrium of hyodeoxycholic acid in ethanol+(acetone, ethyl acetate) binary solvent mixtures

Yang

Cao

et al. 2015

Journal of Molecular Liquids

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Solubility of methylphosphonic acid in selected organic solvents

Cited by 18 publications

References 22 publications

The Impact of Glyphosate, Its Metabolites and Impurities on Viability, ATP Level and Morphological changes in Human Peripheral Blood Mononuclear Cells

The Impact of Glyphosate, Its Metabolites and Impurities on Viability, ATP Level and Morphological changes in Human Peripheral Blood Mononuclear Cells

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

Thermodynamic analysis and correlation of solid–liquid equilibrium of hyodeoxycholic acid in ethanol+(acetone, ethyl acetate) binary solvent mixtures

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